Brain abnormalities in children with attention-deficit/hyperactivity disorder assessed by multi-delay arterial spin labeling perfusion and voxel-based morphometry

• Material Type: 博士論文
• Title: Brain abnormalities in children with attention-deficit/hyperactivity disorder assessed by multi-delay arterial spin labeling perfusion and voxel-based morphometry
• Author/Editor: Gonchigsuren, Oyundari; Harada, Masafumi; Hisaoka, Sonoka; Higashi, Kohei; Matsumoto, Yuki; Sumida, Nami; Mori, Tatsuo; Ito, Hiromichi; Mori, Kenji; Miyoshi, Mitsuharu
• Author Heading: Gonchigsuren, Oyundari; Harada, Masafumi; Hisaoka, Sonoka; Higashi, Kohei; Matsumoto, Yuki; Sumida, Nami; Mori, Tatsuo; Ito, Hiromichi; Mori, Kenji; Miyoshi, Mitsuharu
• Publication, Distribution, etc.: Japan Radiological Society|Springer Nature
• Publication Date: 2022-01-23
• Publication Date (W3CDTF): 2022-01-23
• Alternative Title: マルチディレイ動脈スピンラベリング灌流法とボクセルベースの形態計測によって評価された注意欠陥/多動性障害の子供における脳の異常
• Periodical title: Japanese Journal of Radiology
• ISSN (Periodical Title): ISSN : 1867-1071; ISSN : 1867-108X
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-23
• Dissertation Number: 甲第3595号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Attention-deficit/hyperactivity disorder; Cerebral blood flow; Magnetic resonance imaging; Pediatrics
• Target Audience: 一般
• Note (General): Purpose: To obtain an understanding of the correlation between hemodynamic differences and morphological changes as well as potential sex differences in children with ADHD using multi-delay pseudo-continuous arterial spin labeling (pCASL) imaging and voxel-based morphometry (VBM), especially given that previous findings are limited for girls. Materials and methods: We recruited 23 children with ADHD (mean age, 8.3 years; 19 boys; 4 girls) and 24 children without ADHD (mean age, 9.1 years; 13 boys; 11 girls) as controls. All participants underwent 3D multi-delay pCASL and T1-weighted imaging. The voxel-based statistical parameter mapping (SPM) method was used for group-wise comparisons. Results: Compared with controls, children with ADHD exhibited decreased regional cerebral blood flow (rCBF) and gray matter volume (GMV) in the left middle frontal gyrus and left postcentral gyrus. Analysis by sex revealed reduced rCBF and GMV in the left lingual gyrus and left inferior occipital gyrus in boys with ADHD versus controls and increased rCBF and GMV in the left superior frontal gyrus in girls with ADHD. Conclusion: Although our results are preliminary because of small sample sizes, several brain regions exhibit changes in both cerebral perfusion and GMV in the same direction in patients with ADHD, with boys with ADHD showing decreased activity and girls with ADHD displaying increased activity in the fronto-parietal cortices.
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s11604-021-01239-w
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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