Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes

• Material Type: 博士論文
• Title: Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes
• Author/Editor: Wada, Akihiro; Murakami, Keiji; Ishikawa, Yumi; Amoh, Takashi; Hirao, Kouji; Hosokawa, Yuki; Hinode, Daisuke; Miyake, Yoichiro; Yumoto, Hiromichi
• Author Heading: Wada, Akihiro; Murakami, Keiji; Ishikawa, Yumi; Amoh, Takashi; Hirao, Kouji; Hosokawa, Yuki; Hinode, Daisuke; Miyake, Yoichiro; Yumoto, Hiromichi
• Publication, Distribution, etc.: Hindawi
• Publication Date: 2022-01-04
• Publication Date (W3CDTF): 2022-01-04
• Alternative Title: 口腔上皮細胞に対するJuncus effusus L.水抽出物の抗炎症及び保護効果
• Periodical title: BioMed Research International
• No. or year of volume/issue: 2022
• Volume: 2022
• Pages: 9770899-
• ISSN (Periodical Title): ISSN : 2314-6133; ISSN : 2314-6141
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-23
• Dissertation Number: 甲第3612号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Juncus effusus L; Oral epithelial cells; Toll-like receptor; Lipopolysaccharide; Chemokines
• Target Audience: 一般
• Note (General): Periodontitis is a chronic inflammatory disease caused by periodontopathogenic bacteria that form biofilms in periodontal pockets. The gingival epithelium acts as the first physical barrier in fighting attacks by periodontopathogenic pathogens, such as the primary etiological agent Porphyromonas gingivalis, and various exogenous chemicals, as well as regulates the local innate immune responses. Therefore, the development of novel oral care products to inhibit inflammatory reactions caused by bacterial infection and protect the gingival epithelium is necessary. Juncus effusus L. has generally been used as an indigenous medicine, such as a diuretic, an antipyretic, and an analgesic, in ancient practice. In this study, we examined the effects of a water extract from J. effusus L. on the inhibition of the inflammatory reaction elicited by bacterial infection and protection of the oral epithelium by chemical irritation. Pretreatment of oral epithelial cells with the water extract from J. effusus L. significantly reduced P. gingivalis or its lipopolysaccharide- (LPS-) mediated production of chemokines (interleukin-8 and C-C-chemokine ligand20) in a concentration-dependent manner with comparable to or greater effects than epigallocatechin gallate and protected oral epithelial cells from injury by chemical irritants, cetylpyridinium chloride, and benzethonium chloride. Moreover, the water extract from J. effusus L. in the presence of antimicrobial agents or antifibrinolytics already used as ingredients in mouthwash could significantly reduce the production of chemokines from P. gingivalis LPS-stimulated oral epithelial cells in a concentration-dependent manner. These findings suggest that the water extract from J. effusus L. is potentially useful for oral care to prevent oral infections, such as periodontal infections, and maintain oral epithelial function.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article distributed under the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• Related Material (DOI): 10.1155/2022/9770899
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/117031/20220513164830907909/k3612_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117031/20220513164831655/k3612_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117031/20220513164831150088/k3612_fulltext.pdf fulltext