Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion

• Material Type: 博士論文
• Title: Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion
• Author/Editor: Mitamura, Yoshinori; Enkhmaa, Tserennadmid; Sano, Hiroki; Niki, Masanori; Murao, Fumiko; Egawa, Mariko; Sonoda, Shozo; Sakamoto, Taiji
• Author Heading: Mitamura, Yoshinori; Enkhmaa, Tserennadmid; Sano, Hiroki; Niki, Masanori; Murao, Fumiko; Egawa, Mariko; Sonoda, Shozo; Sakamoto, Taiji
• Publication, Distribution, etc.: BMJ Publishing Group
• Publication Date: 2020-07-03
• Publication Date (W3CDTF): 2020-07-03
• Alternative Title: 網膜静脈閉塞症に対するアフリベルセプト硝子体投与療法後の脈絡膜構造の変化
• Periodical title: British Journal of Ophthalmology
• No. or year of volume/issue: 105 5
• Volume: 105
• Issue: 5
• Pages: 704-710
• ISSN (Periodical Title): ISSN : 0007-1161; ISSN : 1468-2079
• Degree grantor/type: 徳島大学
• Date Granted: 2023-01-26
• Dissertation Number: 甲第3668号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: choroid; imaging; macula; physiology; binarization
• Target Audience: 一般
• Note (General): Aims To examine the choroidal change accompanying retinal vein occlusion (RVO) in detail, we measured changes in choroidal structure after intravitreal aflibercept (IVA) injections for RVO using binarisation of enhanced depth imaging optical coherence tomographic (EDI-OCT) images and assessed associations with clinical outcome. Methods Retrospective, observational case series. Forty treatment-naïve patients (10 central, 18 major branch and 12 macular branch RVO) were examined by EDI-OCT before and 1, 3 and 6 months after IVA injections. EDI-OCT images were binarised using ImageJ. Subfoveal cross-sectional areas of the luminal, stromal and total choroid over a 1500 µm span were measured and the stromal area to total choroidal area (S/C) ratio was calculated. Results Compared to normal contralateral eyes, afflicted eyes at baseline exhibited significantly greater stromal area (p<0.001), total choroidal area (p=0.001) and S/C ratio (p<0.001), but no difference in luminal area (p=0.083). The stromal area, S/C ratio and total choroidal area were significantly reduced in afflicted eyes at 1, 3 and 6 months after IVA (all p<0.006). Baseline S/C ratio was significantly correlated with baseline visual acuity (VA), baseline central retinal thickness (CRT) and VA and CRT improvement at 1, 3 and 6 months post-treatment even after adjusting for the axial length, age and sex (all p<0.012). Conclusion RVO induces substantial oedema of the choroidal stromal area that is detectable by binarisation of EDI-OCT images. This stromal oedema likely stems from high intraocular vascular endothelial growth factor levels. Changes in choroidal structure may be used to assess severity and prognosis of RVO.
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is noncommercial. See: http://creativecommons.org/licenses/by-nc/4.0/
• Related Material (DOI): 10.1136/bjophthalmol-2020-316214
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/117304/20230410094438966254/k3668_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117304/20230410094439220427/k3668_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117304/20230410094439489481/k3668_fulltext.pdf fulltext