Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality : The Japan Multi-Institutional Collaborative Cohort (J-MICC) study

• Material Type: 博士論文
• Title: Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality : The Japan Multi-Institutional Collaborative Cohort (J-MICC) study
• Author/Editor: Nguyen, Tien Van; Arisawa, Kokichi; Katsuura-Kamano, Sakurako; Ishizu, Masashi; Nagayoshi, Mako; Okada, Rieko; Hishida, Asahi; Tamura, Takashi; Hara, Megumi; Tanaka, Keitaro; Nishimoto, Daisaku; Shibuya, Keiichi; Koyama, Teruhide; Watanabe, Isao; Suzuki, Sadao; Nishiyama, Takeshi; Kuriki, Kiyonori; Nakamura, Yasuyuki; Saito, Yoshino; Ikezaki, Hiroaki; Otonari, Jun; Koyanagi, Yuriko N.; Matsuo, Keitaro; Mikami, Haruo; Kusakabe, Miho; Takeuchi, Kenji; Wakai, Kenji
• Author Heading: Nguyen, Tien Van; Arisawa, Kokichi; Katsuura-Kamano, Sakurako; Ishizu, Masashi; Nagayoshi, Mako; Okada, Rieko; Hishida, Asahi; Tamura, Takashi; Hara, Megumi; Tanaka, Keitaro; Nishimoto, Daisaku; Shibuya, Keiichi; Koyama, Teruhide; Watanabe, Isao; Suzuki, Sadao; Nishiyama, Takeshi; Kuriki, Kiyonori; Nakamura, Yasuyuki; Saito, Yoshino; Ikezaki, Hiroaki; Otonari, Jun; Koyanagi, Yuriko N.; Matsuo, Keitaro; Mikami, Haruo; Kusakabe, Miho; Takeuchi, Kenji; Wakai, Kenji
• Publication, Distribution, etc.: PLOS
• Publication Date: 2022-07-08
• Publication Date (W3CDTF): 2022-07-08
• Alternative Title: メタボリックシンドロームおよび代謝的に不健康な肥満とがん死亡率との関連 : 日本多施設共同コーホート（J-MICC）研究; Metabolic syndrome and metabolically unhealthy obesity with cancer mortality
• Periodical title: PLOS ONE
• No. or year of volume/issue: 17 7
• Volume: 17
• Issue: 7
• Pages: e0269550-
• ISSN (Periodical Title): ISSN : 1932-6203
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-23
• Dissertation Number: 甲第3696号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Cancer mortality; Cohort study; Metabolic syndrome; Metabolically unhealthy obesity; Japanese
• Target Audience: 一般
• Note (General): Purpose The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. Methods We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35–69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. Results During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04–2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78–1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05). Conclusion MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• Related Material (DOI): 10.1371/journal.pone.0269550
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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