A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes

• Material Type: 博士論文
• Title: A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes
• Author/Editor: Kamada, Shuhei; Yamamoto, Yuri; Aoki, Hidenori; Tamura, Kou; Takeda, Asuka; Minato, Saki; Masaki, Rie; Yanagihara, Rie; Hayashi, Noriko; Yano, Yuya; Imaizumi, Junki; Kagawa, Tomohiro; Yoshida, Atsuko; Kawakita, Takako; Irahara, Minoru; Iwasa, Takeshi
• Author Heading: Kamada, Shuhei; Yamamoto, Yuri; Aoki, Hidenori; Tamura, Kou; Takeda, Asuka; Minato, Saki; Masaki, Rie; Yanagihara, Rie; Hayashi, Noriko; Yano, Yuya; Imaizumi, Junki; Kagawa, Tomohiro; Yoshida, Atsuko; Kawakita, Takako; Irahara, Minoru; Iwasa, Takeshi
• Publication, Distribution, etc.: Japan Society for Reproductive Medicine|John Wiley & Sons
• Publication Date: 2021-10-02
• Publication Date (W3CDTF): 2021-10-02
• Alternative Title: 新規PCOSラットモデルの作製とその生殖・代謝・行動表現型の評価
• Periodical title: Reproductive Medicine and Biology
• No. or year of volume/issue: 21 1
• Volume: 21
• Issue: 1
• Pages: e12416-
• ISSN (Periodical Title): ISSN : 1447-0578
• Degree grantor/type: 徳島大学
• Date Granted: 2024-03-22
• Dissertation Number: 甲第3796号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: activity; DHT; metabolic; PCOS; reproduction
• Target Audience: 一般
• Note (General): Background: Although animal models of PCOS have been used in many studies, none of them can reproduce both the reproductive and metabolic phenotypes of PCOS. In addition, behavioral parameters have not been evaluated in PCOS animal models. Purpose: We tried to produce an improved rat model of PCOS, and the reproductive, metabolic, and behavioral phenotypes of the model rats were evaluated. Methods: Female rats were implanted with silicon tubes containing oil-dissolved dihydrotestosterone (Oil-DHT) as a new PCOS model. Their phenotypes were compared with those of conventional PCOS model rats (DHT), into which tubes containing crystalline DHT were implanted, and non-DHT-treated rats (control). Results: Both the Oil-DHT and DHT rats showed greater body weight gain, food intake, and fat depot weight than the control rats. Furthermore, these groups showed fewer estrous stages and increased numbers of cystic follicles. The DHT rats exhibited lower ovarian and uterine weights than the control rats, whereas no such changes were observed in the Oil-DHT rats. The Oil-DHT and DHT rats showed less locomotor activity in the light phase than the control rats. Conclusions: Our proposed PCOS model reproduced both the reproductive and metabolic phenotypes of PCOS and may have potential for PCOS research.
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• Related Material (DOI): 10.1002/rmb2.12416
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/117712/20240510093054536271/k3796_abstract.pdf fulltext

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