Prostate-specific Antigen Levels Following Brachytherapy Impact Late Biochemical Recurrence in Japanese Patients With Localized Prostate Cancer

• Material Type: 博士論文
• Title: Prostate-specific Antigen Levels Following Brachytherapy Impact Late Biochemical Recurrence in Japanese Patients With Localized Prostate Cancer
• Author/Editor: Ueno, Yoshiteru; Fukumori, Tomoharu; Kusuhara, Yoshito; Fukawa, Tomoya; Tsuda, Megumi; Daizumoto, Kei; Sasaki, Yutaro; Tomida, Ryotaro; Yamamoto, Yasuyo; Yamaguchi, Kunihisa; Tonoiso, Chisato; Kubo, Akiko; Kawanaka, Takashi; Furutani, Shunsuke; Ikushima, Hitoshi; Takahashi, Masayuki; Kanayama, Hiro-omi
• Author Heading: Ueno, Yoshiteru; Fukumori, Tomoharu; Kusuhara, Yoshito; Fukawa, Tomoya; Tsuda, Megumi; Daizumoto, Kei; Sasaki, Yutaro; Tomida, Ryotaro; Yamamoto, Yasuyo; Yamaguchi, Kunihisa; Tonoiso, Chisato; Kubo, Akiko; Kawanaka, Takashi; Furutani, Shunsuke; Ikushima, Hitoshi; Takahashi, Masayuki; Kanayama, Hiro-omi
• Publication, Distribution, etc.: International Institute of Anticancer Research
• Publication Date: 2023-03-07
• Publication Date (W3CDTF): 2023-03-07
• Alternative Title: 日本人の限局性前立腺癌患者における小線源療法後の前立腺特異抗原レベルは晩期生化学的再発に影響する; Long-term Outcomes of Brachytherapy in Japanese Patients
• Periodical title: in vivo
• No. or year of volume/issue: 37 2
• Volume: 37
• Issue: 2
• Pages: 738-746
• ISSN (Periodical Title): ISSN : 0258-851X; ISSN : 1791-7549
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-03
• Dissertation Number: 甲第3680号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Brachytherapy; Late recurrence; Long-term follow up; Prostate cancer; without external beam radiation; long-term outcomes
• Target Audience: 一般
• Note (General): Background/Aim: Evaluation of long-term outcomes is essential for the successful treatment of localized prostate cancer; however, the risk of late recurrence following brachytherapy is still not clear. This study aimed to evaluate the long-term outcomes of low-dose-rate brachytherapy (LDR-BT) for localized prostate cancer in Japanese patients and identify factors associated with late recurrence after treatment. Patients and Methods: This single-center, cohort study included patients who underwent LDR-BT at the Tokushima University Hospital in Japan between July 2004 and January 2015; 418 patients, who were followed-up at least 7 years after LDR-BT, were included in the study. Biochemical progression free survival (bPFS) was defined according to the Phoenix definition (nadir PSA+2 ng/ml) and bPFS and cancer specific survival (CSS) were calculated using Kaplan-Meier survival curves. Univariate and multivariate analyses were performed using Cox proportional hazard regression models. Results: Approximately half of the patients with PSA >0.5 ng/ml at 5 years after LDR-BT had a recurrence within the next 2 years. However, only 1.4% of the patients with a PSA ≤0.2 ng/ml at 5 years post-treatment showed tumor recurrence, including those at high risk of treatment failure according to the D’Amico classification. In multivariate analysis, PSA level at 5 years post-treatment was the only predictor of late recurrence after 7 years of treatment. Conclusion: PSA levels at 5 years post-treatment were associated with long-term recurrence of localized prostate cancer, which can help alleviate patient anxiety concerning prostate cancer recurrence if PSA levels remain low at 5 years after LDR-BT.
• Access Restrictions: インターネット公開
• Rights (production): This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).
• Related Material (DOI): 10.21873/invivo.13136
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/118238/20230519132740351812/k3680_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118238/20230519132740672484/k3680_review.pdf fulltext

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