Vascular Endothelial Function Is Associated with eGFR Slope in Female and Non-Smoking Male Individuals with Cardiovascular Risk Factors : A Pilot Study on the Predictive Value of FMD for Renal Prognosis

• Material Type: 博士論文
• Title: Vascular Endothelial Function Is Associated with eGFR Slope in Female and Non-Smoking Male Individuals with Cardiovascular Risk Factors : A Pilot Study on the Predictive Value of FMD for Renal Prognosis
• Author/Editor: Masuda, Shiho; Hara, Tomoyo; Yamagami, Hiroki; Mitsui, Yukari; Kurahashi, Kiyoe; Yoshida, Sumiko; Harada, Takeshi; Otoda, Toshiki; Yuasa, Tomoyuki; Nakamura, Shingen; Kuroda, Akio; Endo, Itsuro; Matsumoto, Toshio; Matsuhisa, Munehide; Abe, Masahiro; Aihara, Ken-ichi
• Author Heading: Masuda, Shiho; Hara, Tomoyo; Yamagami, Hiroki; Mitsui, Yukari; Kurahashi, Kiyoe; Yoshida, Sumiko; Harada, Takeshi; Otoda, Toshiki; Yuasa, Tomoyuki; Nakamura, Shingen; Kuroda, Akio; Endo, Itsuro; Matsumoto, Toshio; Matsuhisa, Munehide; Abe, Masahiro; Aihara, Ken-ichi
• Publication, Distribution, etc.: Japan Atherosclerosis Society
• Publication Date: 2023
• Publication Date (W3CDTF): 2023
• Alternative Title: 血管内皮機能は心血管リスクを有する女性および非喫煙男性のeGFR slopeと関連している : 腎予後に対するFMDの予測能に関するパイロット研究; FMD and eGFR Slope in Males and Females
• Periodical title: Journal of Atherosclerosis and Thrombosis
• No. or year of volume/issue: 30 11
• Volume: 30
• Issue: 11
• Pages: 1727-1741
• ISSN (Periodical Title): ISSN : 1880-3873; ISSN : 1340-3478
• Degree grantor/type: 徳島大学
• Date Granted: 2023-09-28
• Dissertation Number: 甲第3755号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Sex difference; FMD; baPWV; eGFR slope; Cigarette smoking
• Target Audience: 一般
• Note (General): Aims: It is known that there are sex differences in vascular endothelial function and the development of chronic kidney diseases; however, it remains unclear whether sex differences influence the association between vascular endothelial function and renal prognosis. Methods: To clarify the relationship between vascular endothelial function and longitudinal eGFR changes in male and female patients with cardiovascular risk factors, we retrospectively evaluated 341 patients (176 males and 165 females) with cardiovascular risk factors in whom vascular function was assessed by flow-mediated dilation (FMD) and brachial ankle pulse wave velocity (baPWV) and in whom 24-month longitudinal eGFR values were recorded after the vascular function examinations. Associations of values of FMD and baPWV with values of eGFR slope were statistically analyzed. Results: Simple regression analysis showed that the value of FMD was positively associated with eGFR slope in females (p=0.001) and non-smoking males (p=0.033) but not in smoking males. Multiple regression analysis showed that the value of FMD remains a positive contributor for eGFR slope in females (p=0.001) and nonsmoking males (p=0.045) but not in smoking males. In contrast, values of baPWV had no significant association with eGFR slope regardless of sex and cigarette smoking. Conclusions: In individuals with cardiovascular risk factors, evaluation of vascular endothelial function enables prediction of renal prognosis in females and non-smoking males.
• Access Restrictions: インターネット公開
• Rights (production): This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.( https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja )
• Related Material (DOI): 10.5551/jat.63987
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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