Stimulation of the farnesoid X receptor promotes M2 macrophage polarization

• Material Type: 博士論文
• Title: Stimulation of the farnesoid X receptor promotes M2 macrophage polarization
• Author/Editor: Jaroonwitchawan, Thiranut; Arimochi, Hideki; Sasaki, Yuki; Ishifune, Chieko; Kondo, Hiroyuki; Otsuka, Kunihiro; Tsukumo, Shin-ichi; Yasutomo, Koji
• Author Heading: Jaroonwitchawan, Thiranut; Arimochi, Hideki; Sasaki, Yuki; Ishifune, Chieko; Kondo, Hiroyuki; Otsuka, Kunihiro; Tsukumo, Shin-ichi; Yasutomo, Koji
• Publication, Distribution, etc.: Frontiers Media S.A.
• Publication Date: 2023-01-27
• Publication Date (W3CDTF): 2023-01-27
• Alternative Title: ファルネソイドX受容体に対する刺激はマクロファージのM2分極化を促進する
• Periodical title: Frontiers in Immunology
• No. or year of volume/issue: 14
• Volume: 14
• Pages: 1065790-
• ISSN (Periodical Title): ISSN : 1664-3224
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-23
• Dissertation Number: 甲第3701号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: ファルネソイドX受容体; ファルネソイドX受容体アゴニスト; M2マクロファージ; レチノール酸受容体; farnesoid X receptor; macrophage; cell differentiation; inflammation; tissue repair
• Target Audience: 一般
• Note (General): FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in macrophage polarization. In this paper we demonstrated that stimulation of macrophages derived from the bone marrow using an FXR agonist activated polarization toward M2 but not M1 macrophages. The treatment of mice with chitin skewed macrophage polarization towards M2 macrophages, while co-treatment with an FXR agonist further promoted the polarization toward M2 macrophages in vivo. This skewed polarization towards M2 macrophages by an FXR agonist was accompanied by increased expression of signaling molecules related to the retinoic acid receptor. Inhibition of the retinoic acid receptor suppressed FXR agonist-mediated M2 macrophage polarization, indicating that this polarization was, at least, partly dependent on the retinoic acid receptor pathway. These data demonstrate that FXR has a role in polarization toward M2 macrophages and suggest a possible therapeutic potential of FXR agonists in M2 macrophage-related conditions.
• Source: comment：fulltext; http://repo.lib.tokushima-u.ac.jp/files/public/11/118291/20230601154839284878/k3701_abstract.pdf; http://repo.lib.tokushima-u.ac.jp/files/public/11/118291/20230601154839587939/k3701_review.pdf; http://repo.lib.tokushima-u.ac.jp/files/public/11/118291/20230601154839886107/k3701_fulltext.pdf
• Access Restrictions: インターネット公開
• Rights (production): This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• Related Material (DOI): 10.3389/fimmu.2023.1065790
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ