Aberrant methylation of dipeptidyl peptidase‑like 6 as a potential prognostic biomarker for lung adenocarcinoma

• Material Type: 博士論文
• Title: Aberrant methylation of dipeptidyl peptidase‑like 6 as a potential prognostic biomarker for lung adenocarcinoma
• Author/Editor: Munkhjargal, Batkhishig; Kondo, Kazuya; Soejima, Shiho; Tegshee, Bilguun; Takai, Chikako; Kawakita, Naoya; Toba, Hiroaki; Takizawa, Hiromitsu
• Author Heading: Munkhjargal, Batkhishig; Kondo, Kazuya; Soejima, Shiho; Tegshee, Bilguun; Takai, Chikako; Kawakita, Naoya; Toba, Hiroaki; Takizawa, Hiromitsu
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2023-04-05
• Publication Date (W3CDTF): 2023-04-05
• Alternative Title: 肺腺癌においてdipeptidyl peptidase‑like 6 (DPP-6)遺伝子のDNAメチル化は予後の指標となる; ABERRANT METHYLATION OF DPP6 IN LUNG ADENOCARCINOMA
• Periodical title: Oncology Letters
• No. or year of volume/issue: 25 5
• Volume: 25
• Issue: 5
• Pages: 206-
• ISSN (Periodical Title): ISSN : 1792-1074; ISSN : 1792-1082
• Degree grantor/type: 徳島大学
• Date Granted: 2024-03-22
• Dissertation Number: 甲第3805号
• Degree Type: 博士（保健学）
• Text Language Code: eng
• Subject Heading: lung cancer; DPP6; DNA; methylation; mRNA expression; prognosis
• Target Audience: 一般
• Note (General): We previously performed the genome‑wide screening of aberrantly methylated CpG islands (CGIs) using the paired tumorous and non‑tumorous tissues of 12 lung adenocarcinomas (LADC). In comparisons with paired normal lung tissues, dipeptidyl peptidase‑like 6 (DPP6) has been identified as the most significantly hypermethylated CGI in LADC. DPP6 is a protein that modulates A‑type potassium channels in the somatodendritic compartments of neurons, which play a role in synaptic plasticity. Previous studies have showed that DPP6 is downregulated in cancers, such as acute myeloid leukemia and melanoma, but upregulated in colon cancer, which is attributed to hyper‑ and hypomethylation, respectively. The present study investigated the methylation and expression levels of DPP6 and its prognostic value in patients with LADC. The DNA methylation and mRNA expression levels of DPP6 in surgically resected LADC tissues were examined by bisulfite pyrosequencing and reverse transcription‑quantitative PCR, respectively. The DNA methylation and mRNA expression levels of DPP6 were both significantly higher in LADC tissues compared with in normal lung tissues (n=25; P<0.0001). Overall and disease‑free survival rates were significantly higher in LADC with high mRNA expression levels compared with those with low levels. In conclusion, epigenetic alterations in DPP6 were significantly higher in LADC tissues compared with in normal lung tissues, which may contribute to the malignant features and worse prognosis of these patients.
• Access Restrictions: インターネット公開
• Rights (production): This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
• Related Material (DOI): 10.3892/ol.2023.13792
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/119342/20240514104520988537/k3805_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119342/2024051410452191020/k3805_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119342/20240514104521179802/k3805_fulltext.pdf fulltext