New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins

• Material Type: 博士論文
• Title: New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins
• Author/Editor: Kagawa, Tomohiro; Mineda, Ayuka; Nakagawa, Tomotaka; Shinohara, Ayaka; Arakaki, Ryosuke; Inui, Hiroaki; Noguchi, Hiroki; Yoshida, Atsuko; Kinouchi, Riyo; Yamamoto, Yuri; Yoshida, Kanako; Kaji, Takashi; Nishimura, Masato; Iwasa, Takeshi
• Author Heading: Kagawa, Tomohiro; Mineda, Ayuka; Nakagawa, Tomotaka; Shinohara, Ayaka; Arakaki, Ryosuke; Inui, Hiroaki; Noguchi, Hiroki; Yoshida, Atsuko; Kinouchi, Riyo; Yamamoto, Yuri; Yoshida, Kanako; Kaji, Takashi; Nishimura, Masato; Iwasa, Takeshi
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2024-03-26
• Publication Date (W3CDTF): 2024-03-26
• Alternative Title: 分泌型frizzled関連蛋白(SFRP)を用いた子宮肉腫に対する新たな治療戦略の検討; UTERINE SARCOMA TREATMENT WITH SECRETED FRIZZLED‑RELATED PROTEINS
• Periodical title: Experimental and Therapeutic Medicine
• No. or year of volume/issue: 27 5
• Volume: 27
• Issue: 5
• Pages: 231-
• ISSN (Periodical Title): ISSN : 1792-0981; ISSN : 1792-1015
• Degree grantor/type: 徳島大学
• Date Granted: 2024-07-25
• Dissertation Number: 甲第3838号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: secreted frizzled‑related protein; uterine sarcoma; Wnt signaling pathway; migration; adhesion
• Target Audience: 一般
• Note (General): Secreted frizzled‑related proteins (SFRPs) are involved in the development of various types of cancer and function by suppressing the Wnt signaling pathway. To elucidate the clinical implications of SFRPs in uterine sarcoma, SFRP expression levels and their effects on uterine leiomyosarcoma cells were examined. Immunostaining for SFRP4 was performed on uterine smooth muscle, uterine fibroid and uterine leiomyosarcoma tissues. Additionally, the effects of SFRP4 administration on cell viability, migration and adhesion were evaluated in uterine leiomyosarcoma SKN cells using the WST‑1 assay (Roche Diagnostics) and the CytoSelect™ 24‑well Cell Migration Assay Kit and the CytoSelect™ 48‑well Cell Adhesion Assay Kit. The expression levels of SFRP4 in uterine leiomyosarcoma tissues were lower than those in normal smooth muscle and uterine fibroid tissues. In addition, SFRP4 suppressed the viability and migration, and increased the adhesion ability of uterine leiomyosarcoma cells compared with in the control group. In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3892/etm.2024.12520
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/119581/20240821132548206700/k3838_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119581/20240821132548411551/k3838_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119581/20240821155214912090/k3838_fulltext.pdf fulltext