Asciminib, a novel allosteric inhibitor of BCR-ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance

• Material Type: 博士論文
• Title: Asciminib, a novel allosteric inhibitor of BCR-ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance
• Author/Editor: 岡本, 尚大; 八木, 健太; Imawaka, Sayaka; Takaoka, Mayu; 相澤, 風花; 新村, 貴博; 合田, 光寛; Miyata, Koji; 川田, 敬; (井澤)石澤, 有紀; 坂口, 暁; 石澤, 啓介
• Author Heading: 岡本, 尚大 オカモト, ナオキ; 八木, 健太 ヤギ, ケンタ; Imawaka, Sayaka; Takaoka, Mayu; 相澤, 風花 アイザワ, フウカ; https://nrid.nii.ac.jp/ja/search/?qm=80848367; 新村, 貴博 ニイムラ, タカヒロ; https://nrid.nii.ac.jp/ja/search/?qm=50910014; 合田, 光寛 ゴウダ, ミツヒロ; https://nrid.nii.ac.jp/ja/search/?qm=40585965; Miyata, Koji; 川田, 敬 カワダ, ケイ; https://nrid.nii.ac.jp/ja/search/?qm=40973772; (井澤)石澤, 有紀 イシザワ, ユキ; https://nrid.nii.ac.jp/ja/search/?qm=40610192; 坂口, 暁 サカグチ, サトシ; 石澤, 啓介 イシザワ, ケイスケ; https://nrid.nii.ac.jp/ja/search/?qm=60398013
• Publication, Distribution, etc.: British Pharmacological Society
• Publication Date: 2024-06-21
• Publication Date (W3CDTF): 2024-06-21
• Alternative Title: 新規BCR-ABL1 アロステリック阻害剤アシミニブは薬剤耐性の有無に関わらずイマチニブとの併用で相乗効果を示す
• Periodical title: Pharmacology Research & Perspectives
• No. or year of volume/issue: 12 4
• Volume: 12
• Issue: 4
• Pages: e1214-
• ISSN (Periodical Title): EISSN : 20521707
• Dissertation Number: 甲医第1616号
• Text Language Code: und
• Subject Heading: CML; chronic myelogenous leukemia; Asciminib; BCR-ABL inhibitors; Drug Resistance
• Target Audience: 一般
• Format (IMT): application/pdf
• Source: fulltext; https://tokushima-u.repo.nii.ac.jp/record/2007994/files/k3845_fulltext.pdf
• Access Restrictions: インターネット公開
• Rights (production): This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

• Summary, etc.: In the treatment of chronic myeloid leukemia (CML), resistance to BCR-ABL inhibitors makes it difficult to continue treatment and is directly related ...