Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model
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- Material Type
- 博士論文
- Author/Editor
- 片木, 淳
- Author Heading
- Publication, Distribution, etc.
- Publication Date
- 2016-03
- Publication Date (W3CDTF)
- 2016-03
- Alternative Title
- なぜdl-sotalol はin vitro でhERG K+チャネル阻害作用が弱いにも関わらずin vivoでQT 間隔を延長するのか?ハロセン麻酔モルモットを用いた電気生理学的および薬物動態学的解析
- Periodical title
- 東邦大学大学院医学研究科 博士論文
- Degree grantor/type
- 東邦大学