Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model

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Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model

Material type: 博士論文

Author: 片木, 淳

Publisher: 東邦大学

Publication date: 2016-03

Material Format: Digital

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Name of awarding university/degree: 東邦大学,博士(医学)

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Note (General)：: type:Doctor Thesis主査 : 池田隆徳 / タイトル : Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitr...

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Material Type: 博士論文
Title: Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model
Author/Editor: 片木, 淳
Author Heading: 片木, 淳
Publication, Distribution, etc.: 東邦大学
Publication Date: 2016-03
Publication Date (W3CDTF): 2016-03
Alternative Title: なぜdl-sotalol はin vitro でhERG K+チャネル阻害作用が弱いにも関わらずin vivoでQT 間隔を延長するのか?ハロセン麻酔モルモットを用いた電気生理学的および薬物動態学的解析
Periodical title: 東邦大学大学院医学研究科博士論文
Degree grantor/type: 東邦大学
Date Granted: 2016-03-29
Dissertation Number: 甲第782号
Degree Type: 博士(医学)
Text Language Code: eng
Target Audience: 一般
Note (General): type:Doctor Thesis
主査 : 池田隆徳 / タイトル : Why can dl-Sotalol prolong the QT interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? Electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea pig model /著者 : Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda,Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama /掲載誌 : Cardiovascular Toxicology /巻号・発行年等 : 16(2):138-146, 2016 /本文ファイル: 査読後原稿 /The final publication is available at Springer via http://dx.doi.org/10.1007/s12012-015-9322-2 /
identifier:http://link.springer.com/article/10.1007%2Fs12012-015-9322-2
Format (IMT): application/pdf
Source: https://mylibrary.toho-u.ac.jp/webopac/bdyview.do?bodyid=TD46968627&elmid=Body&fname=46968627_cover.pdf （fulltext）
https://mylibrary.toho-u.ac.jp/webopac/bdyview.do?bodyid=TD46968627&elmid=Body&fname=46968627_cover.pdf
Access Restrictions: インターネット公開
Related Material (DOI): 10.1007/s12012-015-9322-2
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 東邦大学 : 東邦大学学術リポジトリ