SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition.

• Material Type: 博士論文
• Title: SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition.
• Author/Editor: 富田, 一聖; TOMITA, Issei
• Author Heading: 富田, 一聖; TOMITA, Issei
• Publication, Distribution, etc.: Elsevier B.V.
• Publication Date: 2020
• Publication Date (W3CDTF): 2020
• Periodical title: Cell metabolism
• No. or year of volume/issue: 32 3
• Volume: 32
• Issue: 3
• Pages: 404-419.e6
• ISSN (Periodical Title): EISSN : 1932-7420
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2021-03-09
• Dissertation Number: 甲第899号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: diabetic kidney disease; atherosclerosis; ketone body; SGLT2 inhibitor; lipolysis; ketolysis; mTORC1; nutrient-sensing signal; renal energy; metabolism
• Target Audience: 一般
• Note (General): pdf; Thesis or Dissertation; 令和2年度
• Format (IMT): application/pdf
• Source: j.cmet.2020.06.020 （fulltext）; https://shiga-med.repo.nii.ac.jp/record/3944/files/j.cmet.2020.06.020.pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2020 Elsevier Inc. All rights reserved.
• Related Material: 10.1016/j.cmet.2020.06.020; https://doi.org/10.1016/j.cmet.2020.06.020; 博士論文要旨; http://hdl.handle.net/10422/00012998
• Related Material (DOI): 10.1016/j.cmet.2020.06.020
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 滋賀医科大学 : 滋賀医科大学機関リポジトリびわ庫

• Summary, etc.: SGLT2 inhibitors offer strong renoprotection in subjects with diabetic kidney disease (DKD). But the mechanism for such protection is not clear. Here,...