Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts

• Material Type: 博士論文
• Title: Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts
• Author/Editor: 廣⽥, 秀逸
• Author Heading: 廣⽥, 秀逸
• Publication, Distribution, etc.: 大阪歯科学会
• Alternative Title: マウス⾻髄由来細胞と⾻芽細胞の共培養系でのヒアルロン酸の破⾻細胞分化に及ぼす影響
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2015-03-06
• Dissertation Number: 甲第751号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Hyaluronan; Coculture; Osteoclast differentiation
• Target Audience: 一般
• Note (General): Hyaluronan (HA) is widely used as a disease-modifying drug to reduce pain in patients with osteoarthritis. We investigated whether the commercially available HA product Artz^[○!R] contributes to bone regeneration. To assess whether exogenous HA influences bone resorption and formation, we examined osteoclast differentiation in mouse bone marrow-derived cells co- cultured with primary mouse calvarial osteoblasts, and also analyzed the proliferation and adhesion of these cells. Coculture of osteoblasts and bone marrow cells in the presence of HA resulted in decreased osteoclast differentiation. Cellular proliferation of osteoblasts and bone marrow cells in the presence of HA was significantly greater than in the absence of HA. However, adhesion of bone marrow cells was decreased by HA. The increased proliferation of osteoblasts and decreased number of attached bone marrow cells in the presence of HA lead to an imbalance between the number of these cells, resulting in suppressed osteoclast differentiation.; 2014年度
• Access Restrictions: インターネット公開
• Rights (production): CC BY-NC-ND
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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