Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury

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Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury

Material type: 博士論文

Author: 柿原, 理奈

Publisher: 大阪歯科学会

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Deafferentation of somatosensory trigeminal nerves innervating dental pulp and periodontal tissue results in a higher taste threshold persisting for a...

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Material Type: 博士論文
Title: Activation of microglia in the nucleus of the solitary tract by inferior alveolar nerve injury
Author/Editor: 柿原, 理奈
Author Heading: 柿原, 理奈
Publication, Distribution, etc.: 大阪歯科学会
Alternative Title: 下⻭槽神経損傷による孤束核内のマイクログリアの活性化
Degree grantor/type: 大阪歯科大学
Date Granted: 2015-03-06
Dissertation Number: 甲第746号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: Microglia
Nucleus of solitary tract (NST)
Inferior alveolar nerve (IAN)
Target Audience: 一般
Note (General): Deafferentation of somatosensory trigeminal nerves innervating dental pulp and periodontal tissue results in a higher taste threshold persisting for a long time in humans. The dental and taste nerves converge on neurons in the rostral nucleus of the solitary tract (rNST), suggesting somatosensory and taste input interact in processing taste information in the rNST. Peripheral injury to the inferior alveolar nerve (IAN), one of the dental nerves, leads to glial responses predominantly in the trigeminal spinal subnucleus caudalis and spinal dorsal horn, and abnormal pain sensation via a mechanism involving the active microglia. We examined the microglial response in another primary IAN terminal, the NST, after transection of the IAN (IANx) to reveal a mechanism of abnormal taste sensation after peripheral injury to the dental nerves. By 7 days post-IANx, a cluster of microglial cells appeared in and around the rostral-most portion of the NST, indicating that nerve damage to the IAN results in a microglial response in the rNST, which may participate in initiating abnormal taste sensations following IAN injury.
2014年度
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=34&item_no=1&attribute_id=20&file_no=1
fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=34&item_no=1&attribute_id=20&file_no=2
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ