A novel strategy for preparing nanoporous biphasic calcium phosphate of controlled composition via a modified nanoparticle-assembly method

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A novel strategy for preparing nanoporous biphasic calcium phosphate of controlled composition via a modified nanoparticle-assembly method

Material type: 博士論文

Author: 藤原, 敬子

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Biphasic calcium phosphate (BCP) consisting of hydroxyapatite (HAp) and β-tricalcium phosphate is usually prepared by thermal decomposition of calcium...

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Material Type: 博士論文
Title: A novel strategy for preparing nanoporous biphasic calcium phosphate of controlled composition via a modified nanoparticle-assembly method
Author/Editor: 藤原, 敬子
Author Heading: 藤原, 敬子
Alternative Title: 改良ナノ粒子集積法によるり組成を制御した二相性リン酸カルシウムナノ多孔質体の新規な制作方法
Degree grantor/type: 大阪歯科大学
Date Granted: 2014-03-07
Dissertation Number: 甲第723号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: Assembly
Calcium phosphate
Nanoparticle
Nanopore
Osteoblast
Target Audience: 一般
Note (General): Biphasic calcium phosphate (BCP) consisting of hydroxyapatite (HAp) and β-tricalcium phosphate is usually prepared by thermal decomposition of calcium-deficient HAp (CDHAp). However, the calcium deficiency and morphology of CDHAp are difficult to manipulate in parallel. In this study, we report a novel strategy for controlling the composition of nanoporous BCP by using only CDHAp nanoparticles with specific properties (Ca/P molar ratio, 1.61; particle size, 50 nm) as a building block and by adjusting the calcium deficiency of the nanoparticle-assembled CDHAp (Ca/P molar ratio, 1.50-1.67; pore size, 8 nm) with the addition of water-soluble Ca(NO3)2 or (NH 4)2HPO4. After thermal treatment at 1000 C, the composition of BCP could be predictably controlled by adjusting the Ca/P ratio of the nanoparticle-assembled CDHAp. Changes in the Ca/P ratio did not significantly affect the surface morphology of BCP, but the grain size (210-300 nm) and pore size (140-170 nm) tended to increase slightly as the Ca/P ratio decreased. The porosity significantly decreased upon the addition of Ca salts (porosity, 20%) or PO4 salts (porosity, 14%) compared with that of the sample without additives (porosity, 53%). In vitro tests demonstrated enhanced cell adhesion on nanoporous BCP compared with densely sintered pure HAp, and cell differentiation was promoted on the nanoporous pure HAp.
2013
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Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ