Effect of VCAM-1 on the Differentiation into Osteoclast

Material type: 博士論文

Author: 林, 寛

Publisher: Japanese Association of Regenerative Dentistry

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: In Orthodontic therapy, osteoclast precursors such as monocytes and macrophages migrate from vessels into the periodontium and then different...

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Material Type: 博士論文
Title: Effect of VCAM-1 on the Differentiation into Osteoclast
Author/Editor: 林, 寛
Author Heading: 林, 寛
Publication, Distribution, etc.: Japanese Association of Regenerative Dentistry
Alternative Title: 破骨細胞分化に及ぼすVCAM-1の影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2014-03-07
Dissertation Number: 甲第733号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: osteoclast
FAK
VCAM-1
RANKL
Target Audience: 一般
Note (General): In Orthodontic therapy, osteoclast precursors such as monocytes and macrophages migrate from vessels into the periodontium and then differentiate into osteoclasts, causing bone resorption. Focal adhesion kinase (FAK) is a 125-kDa non-receptor type tyrosine kinase that localizes to focal adhesions. FAK is involved in osteoclastic bone resorption. Vascular cell adhesion molecule-1 (VCAM -1) is bound to VLA-4(very late antigen-4) which is kind of the α4 β1-integrin, and recruits monocytic osteoclast progenitors and elevates local osteoclast activity.In our present study we focused on VCAM-1 /α4 integrin-mediated the differentiation into osteoclasts and found that this type of the differentiation was mediated through FAK. RAW267.4 expressed both α4 integrins, and it was reported that expression of α4 integrin and its counterreceptor, VCAM-1, was not enhanced in response to receptor activator of NF-B ligand (RANKL). Neutralizing antibodies against integrin α4 effectively inhibit the differentiation into osteoclasts and phosphorylation of FAK. These findings establish VCAM-1 regulate the differentiation into osteoclasts in bone.
2013
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=56&item_no=1&attribute_id=20&file_no=1
fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=56&item_no=1&attribute_id=20&file_no=2
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ