Activation of microglial cells in the trigeminal subnucleus caudalis evoked by inflammatory stimulation of the oral mucosa

• Material Type: 博士論文
• Title: Activation of microglial cells in the trigeminal subnucleus caudalis evoked by inflammatory stimulation of the oral mucosa
• Author/Editor: 黄, 宏智
• Author Heading: 黄, 宏智
• Publication, Distribution, etc.: Editorial Board of Okajimas Folia Anatomica Japonica
• Alternative Title: 口腔粘膜への侵害刺激により誘発される三叉神経脊髄路核尾側亜核内マイクログリアへの活性化
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2013-09-25
• Dissertation Number: 乙第1579号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: microglia; Vc; nociception
• Target Audience: 一般
• Note (General): To study the inflammatory hyperalgesia induced by an acute noxious stimulation of oral mucosa with 5% formalin (5%FOR), we performed an immunohistochemical study on the expression of TNFá in the intermolar region of the dorsal lingual eminence (IDLE), and Iba1 and phosphorylated (phospho)- p38 MAPK involved with central nervous system microglial activation in the trigeminal subnucleus caudalis (Vc). The present study observed significantly increased expression of TNFá at either 1h or 24h of 5%FOR nociception, as well as sustained TNFá immunoreactivity in the IDLE. On the other hand, at either 1h or 24h 5%FOR nociception, Iba1- immunoreactive (IR) cells in the Vc were significantly increased after inflammatory stimulation of the IDLE; the increase was more evident at 24h 5%FOR nociception. By using the double-label immunofluorescence technique, the findings in particular demonstrated a significant increase in the number of phospho-p38 MAPK- and Iba1-IR coexpressed cells in the Vc at 24h 5%FOR nociception. The results suggest that 24h persistent microglial activation in subnuclei zonalis and gelatinosus of the Vc is evoked by 5%FOR noxious stimulation of the IDLE oral mucosa, thereby the present study indicates that the MAPK expression plays important roles in microglial activation related with central sensitization and inflammatory hyperalgesia.; 2013
• Access Restrictions: インターネット公開
• Rights (production): CC BY-NC-ND
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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