Effects of glucose concentration on osteogenic differentiation of type Ⅱ diabetes mellitus rat bone marrow-derived mesenchymal stromal cells on a nano-scale modified titanium

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Effects of glucose concentration on osteogenic differentiation of type Ⅱ diabetes mellitus rat bone marrow-derived mesenchymal stromal cells on a nano-scale modified titanium

Material type: 博士論文

Author: 山脇, 勲

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: BACKGROUND AND OBJECTIVE:Diabetes mellitus (DM) is a common disease worldwide. Patients with DM have an increased risk of losing their teeth compared ...

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Material Type: 博士論文
Title: Effects of glucose concentration on osteogenic differentiation of type Ⅱ diabetes mellitus rat bone marrow-derived mesenchymal stromal cells on a nano-scale modified titanium
Author/Editor: 山脇, 勲
Author Heading: 山脇, 勲
Alternative Title: ナノレベル表面構造制御チタン金属上におけるⅡ型糖尿病モデルラット骨髄由来間葉系間質細胞の硬組織分化誘導にグルコース濃度が及ぼす影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2017-03-10
Dissertation Number: 甲第800号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: bone marrow cells
hyperglycemia
osseointegration
titanium dioxide
Target Audience: 一般
Note (General): BACKGROUND AND OBJECTIVE:Diabetes mellitus (DM) is a common disease worldwide. Patients with DM have an increased risk of losing their teeth compared with other individuals. Dental implants are a standard of care for treating partial or full edentulism, and various implant surface treatments have recently been developed to increase dental implant stability. However, some studies have reported that DM reduces osseointegration and the success rate of dental implants. The purpose of this study was to determine the effects of high glucose levels for hard tissue formation on a nano-scale modified titanium surface.MATERIAL AND METHODS:Titanium disks were heated at 600°C for 1 h after treatment with or without 10 m NaOH solution. All disks were incubated with type II DM rat bone marrow-derived mesenchymal stromal cells before exposure to one of four concentrations of glucose (5.5, 8.0, 12.0 or 24.0 mm). The effect of different glucose concentrations on bone marrow-derived mesenchymal stromal cell osteogenesis and inflammatory cytokines on the nano-scale modified titanium surface was evaluated.RESULTS:Alkaline phosphatase activity decreased with increasing glucose concentration. In contrast, osteocalcin production and calcium deposition were significantly decreased at 8.0 mm glucose, but increased with glucose concentrations over 8.0 mm. Differences in calcium/phosphate ratio associated with the various glucose concentrations were similar to osteocalcin production and calcium deposition. Inflammatory cytokines were expressed at high glucose concentrations, but the nano-scale modified titanium surface inhibited the effect of high glucose concentrations.CONCLUSION:High glucose concentration increased hard tissue formation, but the quality of the mineralized tissue decreased. Furthermore, the nano-scale modified titanium surface increased mineralized tissue formation and anti-inflammation, but the quality of hard tissue was dependent on glucose concentration.
2016年度
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=158&item_no=1&attribute_id=20&file_no=2
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=158&item_no=1&attribute_id=20&file_no=1
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Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ