Change of Cytotoxicity Level by the Addition of Nanomaterials

• Material Type: 博士論文
• Title: Change of Cytotoxicity Level by the Addition of Nanomaterials
• Author/Editor: 白井, 翼
• Author Heading: 白井, 翼
• Alternative Title: ナノ材料の添加による細胞毒性レベルの変動
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2017-03-10
• Dissertation Number: 甲第801号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: cytotoxicity; nanomaterial; zinc oxide; Bis-GMA; synergy
• Target Audience: 一般
• Note (General): The development of nanomaterials has promoted a marked improvement of performance and studies on the addition of new functions. Nanomaterials may be combined in many dental component materials in the future. However, at present, the results of studies on the biologi-cal safety of nanomaterials are insufficient. Cells have an active nanomaterial uptake mecha-nism, i.e., phagocytosis, and this is completely different from the mechanism of incorporat-ing dissolved chemical substances. Moreover, products prepared with nanomaterials alone are rarely developed, and nanomaterials are likely to be added to conventional chemical sub-stances. In this case, there are no data on changes in the toxicity caused by interaction be-tween nanomaterials and dissolved chemical substances. Thus, we investigated the cytotoxi-city of nano-zinc oxide alone and changes in the cytotoxicity of Bis-GMA, which is used as a matrix resin monomer of composite resin, at its non-cytotoxic concentration. Bis-GMA cyto-toxicity increased in the nano-zinc oxide group compared with that in the control group in both 2- and 3-dimensional culture using collagen gel. It was clarified that the cytotoxicity of Bis-GMA slightly increased due to interaction in the nano-zinc oxide and Bis-GMA mixture.; 2016年度
• Access Restrictions: インターネット公開
• Rights (production): CC BY-NC-ND
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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