Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma

• Material Type: 博士論文
• Title: Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma
• Author/Editor: 栗岡, 香美
• Author Heading: 栗岡, 香美
• Alternative Title: エナメル上皮腫における上皮間葉転写因子 Snail, Slug, Twist, TGF-β, E-cadherin の発現
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2017-03-10
• Dissertation Number: 甲第802号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Epithelial mesenchymal transition (EMT); Ameloblastoma; Immunohistochemistry; Double immunostaining; Snail; Slug; E-cadherin
• Target Audience: 一般
• Note (General): Epithelial mesenchymal transition (EMT), the transition of epithelial cells into motile mesenchymal cells,plays an important role in embryogenesis, cancer invasion,and metastasis. Ameloblastomas are common epithelialodontogenic tumors, occurring exclusively in the mandible with locally invasive growth. Thirty-seven ameloblastoma cases were evaluated for the involvement of EMT by immunohistochemical staining and western blotting using antibodies against Slug, Snail, Twist, TGF-b, and E-cadherin. Double immunostaining was also performed. Slug and TGF-b were expressed in the nuclei of peripheral and stellate reticulum cells of ameloblastoma nests. Twenty cases of Snail, 36 of Slug, 8 of Twist, and 19 of TGF-b showed strong expression in tumor cells in follicular and plexiform patterns. Expression of Slug and TGF-b increased in regions where the expression of E-cadherin was reduced. EMT was found to be associated with thelocal invasive growth of ameloblastoma. These data suggest that reduced expression of E-cadherin and over-expression of Slug, Snail, and TGF-b induce EMT. Given that ameloblastomas are characterized by local invasiveness, EMT might be related to their development. Thus, strong expression of Slug and TGF-b and reduced expression of E-cadherin might be related to the local invasiveness of ameloblastoma.; 2016年度
• Access Restrictions: インターネット公開
• Rights (production): CC BY-NC-ND
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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