Effect of nano modified titanium surface on adsorption of rat periodontal ligament cells

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Effect of nano modified titanium surface on adsorption of rat periodontal ligament cells

Material type: 博士論文

Author: 原, 弓加里

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: When natural teeth are lost, endosseous implants anchored via intimate bone-to-implant contacts are considered an appropriate replacement. The interac...

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Material Type: 博士論文
Title: Effect of nano modified titanium surface on adsorption of rat periodontal ligament cells
Author/Editor: 原, 弓加里
Author Heading: 原, 弓加里
Alternative Title: 純チタン金属表面上のナノ構造がラット歯根膜細胞の挙動に与える影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2018-03-09
Dissertation Number: 甲第830号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: Periodontal ligament cells
Titanium nanostructures
Implant
Target Audience: 一般
Note (General): When natural teeth are lost, endosseous implants anchored via intimate bone-to-implant contacts are considered an appropriate replacement. The interactions between implants and host tissues depend on several factors. In particular, a growing body of evidence has demonstrated that the surface texture of an implant influences the response of the surrounding cells. Recent studies have shown that treating titanium with aqueous NaOH produces a nanostructured surface texture termed a titanium nanosheet (TNS). Furthermore, it was recently reported that a TNS surface promoted the osteogenic differentiation of rat bone marrow cells. We investigated whether a TNS surface may improve wound healing around endosseous implants. To test this, we assessed the effects of a TNS surface on the adhesion and differentiation of rat periodontal ligament (RPL) cells in vitro. The results demonstrated that RPL cells cultured on a TNS surface showed more adhesion and higher levels of osteogenic differentiation markers (Runx2 expression, alkaline phosphatase activity, calcium deposition, and osteocalcin secretion) than cells cultured on unmodified titanium. These findings indicate that RPL cells have the potential for increased bone formation on a TNS surface. Thus, TNS surface modification may warrant consideration for use in endosseous dental implants.
2017年度
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=192&item_no=1&attribute_id=20&file_no=2
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=192&item_no=1&attribute_id=20&file_no=1
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Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ