Application of hydroxyapatite nanoparticle-assembled powder using basic fibroblast growth factor as a pulp-capping agent

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Application of hydroxyapatite nanoparticle-assembled powder using basic fibroblast growth factor as a pulp-capping agent

Material type: 博士論文

Author: 井村, 和希

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Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: We have previously fabricated hydroxyapatite (HAP) nanoparticle-assembled powder (nano-HAP) plates and granules by assembling low-crystallinity HAP na...

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Material Type: 博士論文
Title: Application of hydroxyapatite nanoparticle-assembled powder using basic fibroblast growth factor as a pulp-capping agent
Author/Editor: 井村, 和希
Author Heading: 井村, 和希
Alternative Title: ナノアパタイト－bFGF 複合体を用いた覆髄剤の応用
Degree grantor/type: 大阪歯科大学
Date Granted: 2019-03-08
Dissertation Number: 甲第836号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: Basic fibroblast growth factor
Hydroxyapatite
Nanoparticle-assembled powder
Pulp-capping agent
Target Audience: 一般
Note (General): We have previously fabricated hydroxyapatite (HAP) nanoparticle-assembled powder (nano-HAP) plates and granules by assembling low-crystallinity HAP nanoparticles without template/binder molecules or high-temperature/pressure treatments. In this study, we combined the nano-HAP with fibroblast growth factor (FGF) 2, which promotes odontoblast differentiation, and used this as a pulpcapping agent for dentin defects created in rat molars. The tissue response was then radiologically and histologically assessed at 1 and 2 weeks after capping, to assess the biocompatibility and ability of this material to promote hard tissue formation. The application of nano-HAP/FGF2 induced the invasion of dental pulp cells and vessels, and was consistently found to stimulate formation of a dentinal bridge containing numerous dentinal tubules. We thus succeeded in treating the pulp exposure by using a physiological approach to promote tissue regeneration. Further investigations should be performed to explain exactly how the nano-HAP/FGF2 combination contributes to calcified tissue formation.
2018年度
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=208&item_no=1&attribute_id=20&file_no=2
fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=208&item_no=1&attribute_id=20&file_no=1
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Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
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Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ