Effect of Amelogenin Coating of a Nano-Modified Titanium Surface on Bioactivty

Material type: 博士論文

Author: 寺田, 知里

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: The interactions between implants and host tissues depend on several factors. In particular, a growing body of evidence has demonstrated that the surf...

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Material Type: 博士論文
Title: Effect of Amelogenin Coating of a Nano-Modified Titanium Surface on Bioactivty
Author/Editor: 寺田, 知里
Author Heading: 寺田, 知里
Alternative Title: ナノ構造析出純チタンへのアメロジェニンのコーティングが生体適合性に与える効果
Degree grantor/type: 大阪歯科大学
Date Granted: 2019-03-08
Dissertation Number: 甲第853号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: amelogenin｜host-implant interaction｜nanostructure｜tissue regeneration
Target Audience: 一般
Note (General): The interactions between implants and host tissues depend on several factors. In particular, a growing body of evidence has demonstrated that the surface texture of an implant influences the response of the surrounding cells. The purpose of this study is to develop new implant materials aiming at the regeneration of periodontal tissues as well as hard tissues by coating nano-modified titanium with amelogenin, which is one of the main proteins contained in Emdogain. We confirmed by quartz crystal microbalance evaluation that amelogenin is easy to adsorb onto the nano-modified titanium surface as a coating. Scanning electron microscopy, scanning probe microscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy analyses confirmed that amelogenin coated the nano-modified titanium surface following alkali-treatment. In vitro evaluation using rat bone marrow and periodontal ligament cells revealed that the initial adhesion of both cell types and the induction of hard tissue differentiation such as cementum were improved by amelogenin coating. Additionally, the formation of new bone in implanted surrounding tissues was observed in in vivo evaluation using rat femurs. Together, these results suggest that this material may serve as a new implant material with the potential to play a major role in the advancement of clinical dentistry.
2018年度
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=224&item_no=1&attribute_id=20&file_no=2
comment：fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=224&item_no=1&attribute_id=20&file_no=1
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ