Morphological influence of osteoporosis and bisphosphonates on mandibular glands of rats

• Material Type: 博士論文
• Title: Morphological influence of osteoporosis and bisphosphonates on mandibular glands of rats
• Author/Editor: 西嶋, 一路
• Author Heading: 西嶋, 一路
• Alternative Title: ラット下顎腺における骨粗鬆症及びビスホスホネート製剤の形態学的影響
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2019-03-27
• Dissertation Number: 乙第1617号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Bisphosphonate｜Microvascular corrosion cast｜Osteoporosis｜Salivary gland
• Target Audience: 一般
• Note (General): Bisphosphonates (BP) are widely used therapeutic agents for osteoporosis (OP). While many OP patients experience dry mouth, no study has investigated the morphological influence of OP and BP on salivary glands. We investigated the morphological influence of BP on mandibular glands using normal rats and an OP rat model. The study included 36, 8-week-old female Wistar rats. We divided them into OP and SH groups (18 animals each). The rats in the OP group underwent bilateral ovariectomy, and the SH group received a sham operation. Nine rats from each group were injected with BP, and the remaining were injected with normal saline. Both mandibular glands were removed from each animal. The bone density of the femur was measured using micro-computed tomography, cross-sectional areas of acini were measured using optical microscopy, diameters of acini and periacinar capillaries were measured using scanning electron microscopy, and statistical analysis (at 5% significance) was performed. Each measurement for the SH-BP and OP-BP groups were significantly smaller than those of the SH-NS and OP-NS groups. The results suggest that BP administration caused atrophic changes to the mandibular gland tissues and miniaturization of capillaries, thereby reducing the volume of saliva secreted.; 2018年度
• Access Restrictions: インターネット公開
• Rights (production): CC BY-NC-ND
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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