Effect of serine protease trypsin on the interaction of RANKL and RANK

Material type: 博士論文

Author: 新谷, 継郎

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Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Recent reports suggest that trypsin and the trypsinlike enzyme tryptase modulate the ability of macrophages to polarize to the M2a phenotype. Trypsin...

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Material Type: 博士論文
Title: Effect of serine protease trypsin on the interaction of RANKL and RANK
Author/Editor: 新谷, 継郎
Author Heading: 新谷, 継郎
Alternative Title: セリンプロテアーゼであるトリプシンがRANKL/RANK相互作用に及ぼす影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2019-03-27
Dissertation Number: 乙第1619号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: Osteoclast
Protease
Trypsin
Target Audience: 一般
Note (General): Recent reports suggest that trypsin and the trypsinlike enzyme tryptase modulate the ability of macrophages to polarize to the M2a phenotype. Trypsin also potentiates mono cytes to differentiate into fibrocytes resulting in enhanced wound healing. Because os teoclasts differentiate from monocyte/macrophage lineage cells, the enzymatic activity might also affect osteoclast differentiation. In this study we examined the effect of tryp sin on the ability of the mouse macrophage cell line RAW 264.7 to differentiate into os teoclasts. We found that trypsin treatment of RAW264.7 cells lowers their ability to differ entiate into osteoclasts in response to RANKL. We also found that trypsin treatment low ered the capacity of RANK to bind its cognate ligand RANKL. Therefore, we concluded that the exposure to trypsin or trypsinlike enzymes might affect macrophage polarization to osteoclasts via degradation of the cell surface receptor RANK.
2018年度
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=228&item_no=1&attribute_id=20&file_no=2
fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=228&item_no=1&attribute_id=20&file_no=1
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ