Jump to main content

博士論文

Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide.

Icons representing 博士論文

Digital data available（大阪歯科大学学術リポジトリ）

Begin reading now

学術機関リポジトリデータベース（IRDB）（機関リポジトリ）

Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide.

Material type
博士論文
Author
塩見, 慧
Publisher
-
Publication date
-
Material Format
Digital
Capacity, size, etc.
-
Name of awarding university/degree
大阪歯科大学,博士（歯学）
View All

Notes on use

Note (General)：

出版タイプ： VoRChronic inflammation contributes to the development of DM and DM-associated complications. Hyperglycemia is a hallmark of DM and may contrib...

Search by Bookstore

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

  • Osaka Dental University Academic Repository

    Digital
    You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
    Osaka Dental University Academic Repository

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type
博士論文
Title
Osteogenic Effects of Glucose Concentration for Human Bone Marrow Stromal Cells after Stimulation with Porphyromonas gingivalis Lipopolysaccharide.
Author/Editor
塩見, 慧
Alternative Title
ヒト骨髄間葉系細胞の硬組織分化における Porphyromonas gingivalis LPS存在下での高グルコース環境の影響
Degree grantor/type
大阪歯科大学
Dissertation Number
甲第877号
Degree Type
博士（歯学）
Subject Heading
Bone marrow cells
Hyperglycemia
Porphyromonas gingivalis
Target Audience
一般
Note (General)
出版タイプ： VoR
Chronic inflammation contributes to the development of DM and DM-associated complications. Hyperglycemia is a hallmark of DM and may contribute to sustained inflammation by increasing the levels of proinflammatory cytokines. However, the mechanisms by which bone-related complications develop in DM after stimulation by the Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) remain unknown. We evaluated the effect of high glucose levels on the biomineralization and inflammation markers in a human osteoblastic cell line, after stimulation with LPS from P. gingivalis. We treated cells with glucose at concentrations 5.5, 8.0, 12 and 24 mM after stimulation with P. gingivalis LPS (1.0 mg/ml) and determined its effects on cell proliferation, alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, calcium deposition, inflammatory cytokines, and osteogenic cytokines. . High glucose concentration decreased hard tissue formation after stimulation by P. gingivalis LPS. Understanding the effect of glucose on osteoblast differentiation and Ca deposition might provide a better understanding of the development and prevention of periodontitis associated with diabetes.
2019年度