New bone ingrowth into β-TCP/HA graft activated with argon plasma: a histomorphometric study on sinus lifting in rabbits

• Material Type: 博士論文
• Title: New bone ingrowth into β-TCP/HA graft activated with argon plasma: a histomorphometric study on sinus lifting in rabbits
• Author/Editor: 田中, 一茂
• Author Heading: 田中, 一茂
• Alternative Title: アルゴンプラズマ活性β-TCP/HA材移植の新生骨成長：ウサギの上顎洞底挙上術での組織形態計測研究
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2021-03-05
• Dissertation Number: 甲第891号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Animal study ｜Sinus floor elevation｜ Bone healing｜ Xenograft; Argon plasma
• Target Audience: 一般
• Note (General): Background: In a previous experimental study, new bone was found growing within granules of HA/β-TCP. In vitroand experimental studies have shown increased protein adsorption and cell adhesion graft material bioactivated with Argon plasma. The aims of the present experiment were to study new bone ingrowth into β-TCP/HA granules used as filler material for sinus lifting and the influence on the healing of the bioactivation of the graft with argon plasma.Methods: Sinus lifting was carried out in 20 rabbits using 60% HA and 40% β-TCP as filler material either bioactivated with argon plasma (plasma group) or left untreated (control group). The antrostomies were closed with collagen membranes. Biopsies representing the healing after 2 and 10 weeks were collected, and ground sections were prepared for histomorphometric analyses. Various regions of the elevated space were analyzed both around (outer bone; OB) and inside (interpenetrating bone network, IBN) the graft particles.Results: After 2 weeks of healing, 8.2% and 9.3% (n = 10; p = 0.635) of total new bone (OB + IBN) was found in the plasma and control groups, respectively. Small fractions of IBN were found, spreading from the periphery inward of the graft particles. After 10 weeks of healing, the total new bone was 34.0% in the plasma and 31.3% in Control groups (n = 9; p = 0.594). The respective fractions of IBN were 18.0% and 16.0%. New bone was penetrating from the peripheral regions inside the remnants of graft particles, where it was forming a network of bridges in continuity to the remnants of biomaterial through its porosities. The biomaterial decreased in proportion between 2 and 10 weeks from 52.1 to 28.3% in the plasma group, and from 52.5% to 31.9% in the control group.Conclusion: The bio-activation with argon plasma on a synthetic graft composed of 60% HA and 40% β-TCP used as filler material for sinus lifting showed a tendency to improve bone formation; however, the difference with the control group was neither statistically significant nor clinically relevant.; 2020年度
• Source: fulltext; https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=278&item_no=1&attribute_id=20&file_no=2; https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=278&item_no=1&attribute_id=20&file_no=1
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ