Enhanced Osseointegration and Bio-Decontamination of Nanostructured Titanium Based on Non-Thermal Atmospheric Pressure Plasma

• Material Type: 博士論文
• Title: Enhanced Osseointegration and Bio-Decontamination of Nanostructured Titanium Based on Non-Thermal Atmospheric Pressure Plasma
• Author/Editor: 曾, 昱豪
• Author Heading: 曾, 昱豪
• Alternative Title: 非熱大気圧プラズマによるナノ構造析出純チタン金属上の強化されたオッセオインテグレーションとバイオ除染
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2021-03-05
• Dissertation Number: 甲第914号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: osseointegration｜biofilm inhibition｜ non-thermal plasma treatment
• Target Audience: 一般
• Note (General): Alkali-treated titanate layer with nanonetwork structures (TNS) is a promising surface for improving osseointegration capacity in implants. Nevertheless, there is a risk of device failure as a result of insu_cient resistance to biofilm contamination. This study tested whether treatment using a handheld non-thermal plasma device could e_ciently eliminate biofilm contamination without destroying the surface nanostructure while re-establishing a surface that promoted new bone generation. TNS specimens were treated by a piezoelectric direct discharge (PDD) plasma generator.The evaluation of initial cell attachment with adhesion images, alkaline phosphatase activity, extracellular matrix mineralization, and expression of genes related to osteogenesis was performed using rat bone marrow mesenchymal stem cells, and the bone response were evaluated in vivo using a rat femur model. Nanotopography and surface roughness did not significantly di_er before and after plasma treatments. Cell and bone formation activity were improved by TNS plasma treatment. Furthermore, plasma treatment e_ectively eliminated biofilm contamination from the surface. These results suggested that this plasma treatment may be a promising approach for the treatment of nanomaterials immediately before implantation and a therapeutic strategy for peri-implantitis.; 2020年度
• Access Restrictions: インターネット公開
• Rights (production): CC BY-NC-ND
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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