Effects of amelogenin synthetic peptide on cell proliferation and cell adhesion in human periodontal ligament stem cells

• Material Type: 博士論文
• Title: Effects of amelogenin synthetic peptide on cell proliferation and cell adhesion in human periodontal ligament stem cells
• Author/Editor: 陳, 怡潔
• Author Heading: 陳, 怡潔
• Alternative Title: ヒト歯根膜幹細胞に対するアメロジェニンペプチドの増殖と接着への影響
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2021-09-22
• Dissertation Number: 乙第1637号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Enamel matrix derivative; Periodontal ligament stem cells; MAP kinase signal
• Target Audience: 一般
• Note (General): In our previous study, we constructed a synthetic peptide (SP) derived from enamel matrix derivative that had the potential to form hard tissue. Periodontal ligament stem cells (PDLSCs) can contribute to periodontal tissue regeneration. We investigated the effect of SP on human PDLSCs obtained from healthy adult human third molars. Cell proliferation and cell adhesion were examined by culturing the PDLSCs with and without the SP. The effect of SP on the ERK 1/2 pathway was investigated by western blot analysis. The proliferation of PDLSCs were promoted by SP, which significantly enhanced the cell adhesion of the PDLSCs. The ERK 1/2 signaling pathway was activated by SP and the molecular effect was suppressed by ERK 1/2 specific inhibitor (PD98059). We hypothesized that SP activated the cell proliferation and cell adhesion through the ERK 1/2 pathway. These results indicated that SP might enhance periodontal tissue regeneration.; 2021年度
• Access Restrictions: インターネット公開
• Rights (production): CC BY-NC-ND
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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