Effects of amelogenin synthetic peptide on cell proliferation and cell adhesion in human periodontal ligament stem cells

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Effects of amelogenin synthetic peptide on cell proliferation and cell adhesion in human periodontal ligament stem cells

Material type: 博士論文

Author: 陳, 怡潔

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: 出版タイプ： VoRIn our previous study, we constructed a synthetic peptide (SP) derived from enamel matrix derivative that had the potential to form hard tis...

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Material Type: 博士論文
Title: Effects of amelogenin synthetic peptide on cell proliferation and cell adhesion in human periodontal ligament stem cells
Author/Editor: 陳, 怡潔
Alternative Title: ヒト歯根膜幹細胞に対するアメロジェニンペプチドの増殖と接着への影響
Degree grantor/type: 大阪歯科大学
Dissertation Number: 乙第1637号
Degree Type: 博士（歯学）
Subject Heading: Enamel matrix derivative
Periodontal ligament stem cells
MAP kinase signal
Target Audience: 一般
Note (General): 出版タイプ： VoR
In our previous study, we constructed a synthetic peptide (SP) derived from enamel matrix derivative that had the potential to form hard tissue. Periodontal ligament stem cells (PDLSCs) can contribute to periodontal tissue regeneration. We investigated the effect of SP on human PDLSCs obtained from healthy adult human third molars. Cell proliferation and cell adhesion were examined by culturing the PDLSCs with and without the SP. The effect of SP on the ERK 1/2 pathway was investigated by western blot analysis. The proliferation of PDLSCs were promoted by SP, which significantly enhanced the cell adhesion of the PDLSCs. The ERK 1/2 signaling pathway was activated by SP and the molecular effect was suppressed by ERK 1/2 specific inhibitor (PD98059). We hypothesized that SP activated the cell proliferation and cell adhesion through the ERK 1/2 pathway. These results indicated that SP might enhance periodontal tissue regeneration.
2021年度
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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=308&item_no=1&attribute_id=20&file_no=2
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Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ