The Role of Syndecans in the Human Dental Pulp

• Material Type: 博士論文
• Title: The Role of Syndecans in the Human Dental Pulp
• Author/Editor: 津田, 賢治
• Author Heading: 津田, 賢治
• Alternative Title: ヒト歯髄におけるシンデカンの役割
• Degree grantor/type: 大阪歯科大学
• Date Granted: 2022-03-04
• Dissertation Number: 甲第916号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: dental pulp cells; inflammation; syndecans
• Target Audience: 一般
• Note (General): Objectives: Syndecans (SDCs) are a family of cell surface heparan sulfate proteoglycans known to play critical roles in regulating multiple cellular functions, including participation in inflammation and wound healing as a host defense mole-cule. The present study was undertaken to analyze the role of syndecan family in human dental pulp cells and the effect of an inflammatory cytokine. Materials and methods: Human dental pulp cell cultures from impacted third molars were established. Cells were cultured with the inflammatory mediator in-terleukin-1beta (IL-1beta). The gene expressions of SDCs were analysed by quan-titative RT-PCR. Results and significance: The relative level of mRNA expressions for SDC1 and SDC2 increased with cell proliferation, but both of them were suppressed signifi-cantly by IL-1beta stimulation. The expression of SDC3 remained unaltered by IL-1beta, although the expression level for SDC4 showed a rapid and strong increase. SDC4 was shed into the culture medium in a process involving MMPs. Shedding of SDC4 was increased after IL-1beta-stimulation. Our data demon-strate that all of SDC family express in human dental pulp cells and play different roles, and, most notably, SDC4 is involved in acute inflammation.; 2021年度
• Access Restrictions: インターネット公開
• Rights (production): CC BY-NC-ND
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ

Table of Contents

https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=313&item_no=1&attribute_id=20&file_no=2 fulltext

https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=313&item_no=1&attribute_id=20&file_no=1 fulltext