The Role of Syndecans in the Human Dental Pulp

Material type: 博士論文

Author: 津田, 賢治

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Objectives: Syndecans (SDCs) are a family of cell surface heparan sulfate proteoglycans known to play critical roles in regulating multiple cellular...

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Osaka Dental University Academic Repository
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Material Type: 博士論文
Title: The Role of Syndecans in the Human Dental Pulp
Author/Editor: 津田, 賢治
Author Heading: 津田, 賢治
Alternative Title: ヒト歯髄におけるシンデカンの役割
Degree grantor/type: 大阪歯科大学
Date Granted: 2022-03-04
Dissertation Number: 甲第916号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: dental pulp cells
inflammation
syndecans
Target Audience: 一般
Note (General): Objectives: Syndecans (SDCs) are a family of cell surface heparan sulfate proteoglycans known to play critical roles in regulating multiple cellular functions, including participation in inflammation and wound healing as a host defense mole-cule. The present study was undertaken to analyze the role of syndecan family in human dental pulp cells and the effect of an inflammatory cytokine. Materials and methods: Human dental pulp cell cultures from impacted third molars were established. Cells were cultured with the inflammatory mediator in-terleukin-1beta (IL-1beta). The gene expressions of SDCs were analysed by quan-titative RT-PCR. Results and significance: The relative level of mRNA expressions for SDC1 and SDC2 increased with cell proliferation, but both of them were suppressed signifi-cantly by IL-1beta stimulation. The expression of SDC3 remained unaltered by IL-1beta, although the expression level for SDC4 showed a rapid and strong increase. SDC4 was shed into the culture medium in a process involving MMPs. Shedding of SDC4 was increased after IL-1beta-stimulation. Our data demon-strate that all of SDC family express in human dental pulp cells and play different roles, and, most notably, SDC4 is involved in acute inflammation.
2021年度
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=313&item_no=1&attribute_id=20&file_no=2
fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=313&item_no=1&attribute_id=20&file_no=1
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ