Glucose Affects the Quality and Properties of Hard Tissue in Diabetes Mellitus Model

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Glucose Affects the Quality and Properties of Hard Tissue in Diabetes Mellitus Model

Material type: 博士論文

Author: 武, 慶超

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: Patients with diabetes mellitus (DM) are at an increased risk of tooth loss compared to healthy individuals. Although studies human subjects suggest t...

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Material Type: 博士論文
Title: Glucose Affects the Quality and Properties of Hard Tissue in Diabetes Mellitus Model
Author/Editor: 武, 慶超
Author Heading: 武, 慶超
Alternative Title: グルコースがⅡ型糖尿病モデルラット骨髄間葉系細胞の幹性と硬組織形成に及ぼす影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2022-03-04
Dissertation Number: 甲第924号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: Bone marrow cells
Hyperglycemia
Stemness
Hard tissue formation
Target Audience: 一般
Note (General): Patients with diabetes mellitus (DM) are at an increased risk of tooth loss compared to healthy individuals. Although studies human subjects suggest that diabetes control is affected by periodontitis, there is scarce mechanistic evidence supporting its biological plausibility. Therefore, using type 2 DM rat bone marrow mesenchymal stromal cells (BMMSCs) were incubated with four concentrations of glucose (5.5, 8.0, 12.0 or 24.0 mM), the effects of different glucose concentrations on BMMSCs stemness and osteogenesis were evaluated. High glucose concentrations decreased the fluorescence intensity of β-actin, STRO-1, CD73 and CD90. Moreover, cell proliferation decreased at high glucose concentrations. Alkaline phosphatase activity was decreased at 12.0 mM and 24.0 mM. In contrast, osteocalcin production and calcium deposition were considerably increased at 24.0 mM. Differences in the calcium/phosphate ratio associated with various glucose concentrations were similar to calcium deposition. The mRNA expression of Runx2 and inflammatory cytokines increased with increasing glucose concentration. The RANKL/OPG ratio decreased at high glucose concentrations. A high glucose concentration increased hard tissue formation, but the quality and stemness of the mineralized tissue decreased. Thus, hard tissue had a high risk of bone resorption in the case of uncontrolled diabetes even if periodontal treatment stabilized state of periodontitis for a moment.
2021年度
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Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ