実験動物を用いた酢酸の肥満抑制効果の評価

Material type: 文書・図像類

Author: 山下, 広美

Publisher: 岡山実験動物研究会

Publication date: 2014-04

Material Format: Digital

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Note (General)：: Acetate is an endogenous metabolite of fatty acid β-oxidation in the liver mitochondria under starved condition. Orally administered acetate is readil...

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Material Type: 文書・図像類
Title: 実験動物を用いた酢酸の肥満抑制効果の評価
Author/Editor: 山下, 広美
Author Heading: 山下, 広美
Publication, Distribution, etc.: 岡山実験動物研究会
Publication Date: 2014-04
Publication Date (W3CDTF): 2014-04
Alternative Title: Assessment of acetate on anti-obesity effect with experimental animal
Periodical title: 岡山実験動物研究会報
No. or year of volume/issue: 30
Volume: 30
Pages: 8-10
Text Language Code: jpn
Target Audience: 一般
Note (General): Acetate is an endogenous metabolite of fatty acid β-oxidation in the liver mitochondria under starved condition. Orally administered acetate is readily absorbed in the blood stream and then taken up by tissues and activates AMP-activated protein kinase (AMPK) by increasing the AMP/ATP ratio. Administered acetate shows a marked reduction in lipid accumulation in the adipose tissue, protection against accumulation of fat in the liver, and improves glucose tolerance. It decreases the transcripts of the lipogenic genes in the liver, indicating an inhibition of lipogenesis in that organ. Furthermore, acetate treatment shows a higher rate of oxygen consumption and a smaller size of lipid droplets in white and brown adipose tissues. It is indicated that acetate taken up has a potential to prevent obesity and obesity-linked type 2 diabetes.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 岡山大学 : 岡山大学学術成果リポジトリ