遺伝子改変マウスを利用した生体内間葉系幹細胞の階層性の理解

Material type: 文書・図像類

Author: 宝田, 剛志

Publisher: 岡山実験動物研究会

Publication date: 2017-04

Material Format: Digital

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Note (General)：: Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, includi...

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Material Type: 文書・図像類
Title: 遺伝子改変マウスを利用した生体内間葉系幹細胞の階層性の理解
Author/Editor: 宝田, 剛志
Author Heading: 宝田, 剛志
Publication, Distribution, etc.: 岡山実験動物研究会
Publication Date: 2017-04
Publication Date (W3CDTF): 2017-04
Alternative Title: Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics
Periodical title: 岡山実験動物研究会報
No. or year of volume/issue: 33
Volume: 33
Pages: 15-17
Text Language Code: jpn
Target Audience: 一般
Note (General): Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1−/− mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1− cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1−cells, then Osx+Prx1−Sca1− osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts.
Source: https://ousar.lib.okayama-u.ac.jp/files/public/5/55186/20170602132450537171/poalas_033_015_017.pdf
https://ousar.lib.okayama-u.ac.jp/files/public/5/55186/20170602132450537171/poalas_033_015_017.pdf
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 岡山大学 : 岡山大学学術成果リポジトリ