An Electron Tomographic Analysis of Giantin-Deficient Golgi Proposes a New Function of the Golgin Protein Family

Material type: 図書

Author: Satoh, Ayanoほか

Publisher: Humana New York

Publication date: 2022-12-14

Material Format: Paper

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Note (General)：: The Golgi apparatus is an organelle that mediates modifications, sorting, and transport of proteins and lipids. Golgins are a group of proteins with c...

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Paper

Material Type: 図書
Title: An Electron Tomographic Analysis of Giantin-Deficient Golgi Proposes a New Function of the Golgin Protein Family
Author/Editor: Satoh, Ayano
Hayashi-Nishino, Mitsuko
Nishino, Kunihiko
Author Heading: Satoh, Ayano
Hayashi-Nishino, Mitsuko
Nishino, Kunihiko
Publication, Distribution, etc.: Humana New York
Publication Date: 2022-12-14
Publication Date (W3CDTF): 2022-12-14
Periodical title: Golgi
Pages: 235-246
Text Language Code: eng
Subject Heading: Golgi
Golgin
Giantin
Electron tomography
3D modeling
Vesicles
Target Audience: 一般
Note (General): The Golgi apparatus is an organelle that mediates modifications, sorting, and transport of proteins and lipids. Golgins are a group of proteins with coiled-coil structures that localize to the Golgi and are thought to function as tethers to facilitate the docking of vesicles, Rab GTPases, and cytoskeleton components to the Golgi stack. Giantin is the longest golgin and has been thought to function as a tether for COPI vesicles along with other golgins, such as p115 and GM130. Contrary to our expectation that the loss of the tether will result in an increase in untethered COPI vesicles in the cytoplasm, our electron microscopy observations showed that the fenestrae normally present in Golgi cisternae were reduced upon Giantin knockdown. We also found that this structural change is accompanied by altered secretion of cargo proteins and cell surface glycosylation. These results indicate that there exists a correlation between Golgi structural changes caused by the loss of Giantin and Golgi function. Here, we describe electron tomography methods for the detection of structural changes in the Golgi.
Related Material (DOI): 10.1007/978-1-0716-2639-9_15
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 岡山大学 : 岡山大学学術成果リポジトリ