Size, polyglycerol grafting, and net surface charge of iron oxide nanoparticles determine their interaction and toxicity in Caenorhabditis elegans

Material type: 文書・図像類

Author: Zou, Yajuanほか

Publisher: Elsevier BV

Publication date: 2024-06

Material Format: Digital

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Note (General)：: The widespread application of engineered nanoparticles (NPs) in environmental remediation has raised public concerns about their toxicity to aquatic o...

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Material Type: 文書・図像類
Title: Size, polyglycerol grafting, and net surface charge of iron oxide nanoparticles determine their interaction and toxicity in Caenorhabditis elegans
Author/Editor: Zou, Yajuan
Shikano, Yutaka
Nishina, Yuta
Komatsu, Naoki
Kage-Nakadai, Eriko
Fujiwara, Masazumi
Author Heading: Zou, Yajuan
Shikano, Yutaka
Nishina, Yuta
Komatsu, Naoki
Kage-Nakadai, Eriko
Fujiwara, Masazumi
Publication, Distribution, etc.: Elsevier BV
Publication Date: 2024-06
Publication Date (W3CDTF): 2024-06
Periodical title: Chemosphere
No. or year of volume/issue: 358
Volume: 358
Pages: 142060-
ISSN (Periodical Title): ISSN : 0045-6535
Text Language Code: eng
Subject Heading: iron oxide nanoparticles
polyglycerol functionalization
C. elegans
accumulation
distribution
toxicity
Target Audience: 一般
Note (General): The widespread application of engineered nanoparticles (NPs) in environmental remediation has raised public concerns about their toxicity to aquatic organisms. Although appropriate surface modification can mitigate the ecotoxicity of NPs, the lack of polymer coating to inhibit toxicity completely and the insufficient knowledge about charge effect hinder the development of safe nanomaterials. Herein, we explored the potential of polyglycerol (PG) functionalization in alleviating the environmental risks of NPs. Iron oxide NPs (ION) of 20, 100, and 200 nm sizes (IONS, IONM and IONL, respectively) were grafted with PG to afford ION-PG. We examined the interaction of ION and ION-PG with Caenorhabditis elegans (C. elegans) and found that PG suppressed non-specific interaction of ION with C. elegans to reduce their accumulation and to inhibit their translocation. Particularly, IONS-PG was completely excluded from worms of all developmental stages. By covalently introducing sulfate, carboxyl and amino groups onto IONS-PG, we further demonstrated that positively charged IONS-PG-NH3+ induced high intestinal accumulation, cuticle adhesion and distal translocation, whereas the negatively charged IONS-PG-OSO3– and IONS-PG-COO– were excreted out. Consequently, no apparent deleterious effects on brood size and life span were observed in worms treated by IONS-PG and IONS-PG bearing negatively charged groups. This study presents new surface functionalization approaches for developing ecofriendly nanomaterials.
Source: https://ousar.lib.okayama-u.ac.jp/files/public/6/66966/20240507094015507765/fulltext20240501-01.pdf
https://ousar.lib.okayama-u.ac.jp/files/public/6/66966/20240507094015507765/fulltext20240501-01.pdf
Access Restrictions: 限定公開
Related Material (DOI): 10.1016/j.chemosphere.2024.142060
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 岡山大学 : 岡山大学学術成果リポジトリ