Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign: analysis of layer-specific marker expression

• Material Type: 博士論文
• Title: Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign: analysis of layer-specific marker expression
• Author/Editor: Sakakibara, Takafumi; Sukigara, Sayuri; Saito, Takashi; Otsuki, Taisuke; Takahashi, Akio; Kaneko, Yuu; Kaido, Takanobu; Saito, Yuko; Sato, Noriko; Kimura, Yukio; Nakagawa, Eiji; Sugai, Kenji; Sasaki, Masayuki; Goto, Yu-ichi; Itoh, Masayuki
• Author Heading: Sakakibara, Takafumi; Sukigara, Sayuri; Saito, Takashi; Otsuki, Taisuke; Takahashi, Akio; Kaneko, Yuu; Kaido, Takanobu; Saito, Yuko; Sato, Noriko; Kimura, Yukio; Nakagawa, Eiji; Sugai, Kenji; Sasaki, Masayuki; Goto, Yu-ichi; Itoh, Masayuki
• Publication, Distribution, etc.: Waverly Press
• Publication Date: 2012-08
• Publication Date (W3CDTF): 2012-08
• Alternative Title: “Transmantle sign”を示す限局性皮質異形成における神経細胞の成熟と分化の未熟性：層特異的マーカー発現による解析
• Periodical title: Journal of neuropathology and experimental neurology
• No. or year of volume/issue: 71 8
• Volume: 71
• Issue: 8
• Pages: 741-749
• ISSN (Periodical Title): ISSN : 0022-3069
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-05-29
• Dissertation Number: 乙第1312号
• Degree Type: 博士（医学）
• Text Language Code: und
• Subject Heading: Epilepsy; Focal cortical dysplasia; Layer-specific markers; Neural maturation; Transmantle dysplasia; Transmantle sign
• Target Audience: 一般
• Note (General): type:Thesis; Transmantle dysplasia is a rare type of focal cortical dysplasia (FCD) characterized by expansion of the cortex from the deep white matter to the surface and in which there is a FCD IIA or IIB pathologic pattern. To characterize possible mechanisms underlying this regional disorder of radial migrating cells, we studied the expression patterns of neocortical layer-specific markers using immunohistochemistry in surgical specimens from 5 FCD IIA and 4 FCD IIB cases in children. All neuronal cells expressed the mature neuron marker MAP2/2B but not the microglia markers Iba-1 and CD68. Some layer-specific markers showed distinct expression patterns. TBR1-positive, SATB2-positive, and FOXP1-positive cells were diffusely distributed in the cortex and/or the white matter. TBR1-positive and FOXP1-positive cells were generally more numerous in FCD IIB than in FCD IIA and were mostly in the cortical molecular and upper layers. FOXP1-, FOXP2-, and CUTL1-positive cells also expressed the immature neuron marker, Nestin/PROX1, whereas TBR1-, CTIP2-, and SATB2-positive cells only expressed MAP2/2B. These data highlight differences between FCD IIB and FCD IIA with more cells having the immature marker in upper layer markers in the former. By analyzing layer-specific marker expression patterns, we identified apparent neuronal maturation differences between FCD IIA and FCD IIB in cases of transmantle dysplasia.; 博士（医学）・乙第1312号・平成25年5月29日; identifier:Journal of neuropathology and experimental neurology Vol.71 No.8 p.741-749; identifier:00223069; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2590; identifier:Journal of neuropathology and experimental neurology, 71(8): 741-749
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2590/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2590/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2590/6/03%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1097/NEN.0b013e318262e41a
• Periodical Title (NCID): AA00703323; https://ci.nii.ac.jp/ncid/AA00703323
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU