Coagulation potential of immobilised factor VIII in flow-dependent fibrin generation on platelet surfaces.

• Material Type: 博士論文
• Title: Coagulation potential of immobilised factor VIII in flow-dependent fibrin generation on platelet surfaces.
• Author/Editor: Doi, Masaaki; Sugimoto, Mitsuhiko; Matsui, Hideto; Matsunari, Yasunori; Shima, Midori
• Author Heading: Doi, Masaaki; Sugimoto, Mitsuhiko; Matsui, Hideto; Matsunari, Yasunori; Shima, Midori
• Publication, Distribution, etc.: Schattauer
• Publication Date: 2013-08
• Publication Date (W3CDTF): 2013-08
• Periodical title: Thrombosis and haemostasis
• No. or year of volume/issue: 110 2
• Volume: 110
• Issue: 2
• Pages: 316-322
• ISSN (Periodical Title): ISSN : 0340-6245
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-07-22
• Dissertation Number: 甲第602号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Haemophilia; von Willebrand factor; factor VIII; flow; Fibrin generation
• Target Audience: 一般
• Note (General): type:Thesis; Coagulation factor VIII (FVIII) plays an essential role in haemostasis. To date, physiologic activity of FVIII circulating in the bloodstream (S-FVIII) is evaluated by classic coagulation assays. However, the functional relevance of FVIII (-von Willebrand factor complex) immobilised on thrombogenic surfaces (I-FVIII) remains unclear. We used an in vitro perfusion chamber system to evaluate the function of I-FVIII in the process of mural thrombus formation under whole blood flow conditions. In perfusion of either control or synthetic haemophilic blood, the intra-thrombus fibrin generation on platelet surfaces significantly increased as a function of I-FVIII, independent of S-FVIII, under high shear rate conditions. This I-FVIII effect was unvarying regardless of anti-FVIII inhibitor levels in synthetic haemophilic blood. Thus, our results illustrate coagulation potentials of immobilised clotting factors, distinct from those in the bloodstream, under physiologic flow conditions and may give a clue for novel therapeutic approaches for haemophilic patients with anti-FVIII inhibitors.; 博士（医学）・甲第602号・平成25年7月22日; The definitive version is available at " http://dx.doi.org/10.1160/TH13-02-0159 "; identifier:Thrombosis and haemostasis Vol.110 No.2 p.316-322; identifier:03406245; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2636; identifier:Thrombosis and haemostasis, 110(2): 316-322
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1160/TH13-02-0159
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

Table of Contents

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2636/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2636/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2636/4/03%e6%9c%ac%e6%96%87.pdf fulltext