Ratio of von Willebrand factor propeptide to ADAMTS13 is associated with severity of sepsis.

• Material Type: 博士論文
• Title: Ratio of von Willebrand factor propeptide to ADAMTS13 is associated with severity of sepsis.
• Author/Editor: Fukushima, Hidetada; Nishio, Kenji; Asai, Hideki; Watanabe, Tomoo; Seki, Tadahiko; Matsui, Hideto; Sugimoto, Mitsuhiko; Matsumoto, Masanori; Fujimura, Yoshihiro; Okuchi, Kazuo
• Author Heading: Fukushima, Hidetada; Nishio, Kenji; Asai, Hideki; Watanabe, Tomoo; Seki, Tadahiko; Matsui, Hideto; Sugimoto, Mitsuhiko; Matsumoto, Masanori; Fujimura, Yoshihiro; Okuchi, Kazuo
• Publication, Distribution, etc.: Lippincott, Williams & Wilkins
• Publication Date: 2013-05
• Publication Date (W3CDTF): 2013-05
• Periodical title: Shock
• No. or year of volume/issue: 39 5
• Volume: 39
• Issue: 5
• Pages: 409-414
• ISSN (Periodical Title): ISSN : 1073-2322
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-07-22
• Dissertation Number: 乙第1318号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: sepsis; von Willebrand factor propeptide; ADAMTS13; multiple organ dysfunction
• Target Audience: 一般
• Note (General): type:Thesis; Von Willebrand factor (VWF)-cleaving protease (ADAMTS13) cleaves ultralarge VWF (ULVWF) secreted from endothelium and by which is regulating its physiologic function. An imbalance between ULVWF secretion and ADAMTS13 level occurs in sepsis and may cause multiple organ dysfunction. We evaluated the association between the VWF-propeptide (VWF-pp)/ADAMTS13 ratio and disease severity in patients with severe sepsis or septic shock. In 27 patients with severe sepsis or septic shock and platelet count less than 120,000/μL, we measured plasma VWF, VWF-pp, and ADAMTS13 levels on hospital days 1, 3, 5, and 7. The VWF-pp/ADAMTS13 ratio was increased greater than 12-fold in patients with severe sepsis or septic shock on day 1 and remained markedly high on days 3, 5, and 7 compared with normal control subjects. The VWF-pp/ADAMTS13 ratio significantly correlated with Acute Physiology and Chronic Health Evaluation II score on days 1 and 5; Sepsis-related Organ Failure Assessment score on days 1, 3, and 5; maximum Sepsis-related Organ Failure Assessment score and tumor necrosis factor α level on days 1, 3, 5, and 7; and creatinine level on days 1, 5, and 7. Patients with greater than stage 1 acute kidney injury had significantly higher VWF-pp/ADAMTS13 ratio than patients without acute kidney injury. In summary, the VWF-pp/ADAMTS13 ratio was associated with disease severity in patients with severe sepsis or septic shock and may help identify patients at risk for multiple organ dysfunction by detecting severe imbalance between ULVWF secretion and ADAMTS13 level.; 博士（医学）・乙第1318号・平成25年7月22日; identifier:Shock Vol.39 No.5 p.409-414; identifier:10732322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2640; identifier:Shock, 39(5): 409-414
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1097/SHK.0b013e3182908ea7
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

Table of Contents

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2640/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2640/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2640/4/03%e6%9c%ac%e6%96%87.pdf fulltext