Abnormal distribution of aquaporin-5 and lymphoid infiltration in salivary glands of primary sjögren's syndrome.

• Material Type: 博士論文
• Title: Abnormal distribution of aquaporin-5 and lymphoid infiltration in salivary glands of primary sjögren's syndrome.
• Author/Editor: Kobayashi, Takehiko; Fujimoto, Takashi; Yane, Katsunari; Hosoi, Hiroshi
• Author Heading: Kobayashi, Takehiko; Fujimoto, Takashi; Yane, Katsunari; Hosoi, Hiroshi
• Publication, Distribution, etc.: 奈良医学会
• Publication Date: 2013-11-30
• Publication Date (W3CDTF): 2013-11-30
• Alternative Title: 原発性シェーグレン症候群の唾液腺におけるリンパ球浸潤とアクアポリン5の分布異常について
• Periodical title: Journal of Nara Medical Association
• No. or year of volume/issue: 64 4
• Volume: 64
• Issue: 4
• Pages: 65-72
• ISSN (Periodical Title): ISSN : 1345-0069
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-03-17
• Dissertation Number: 乙第1334号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: aquaporin-5; salivary gland; Sjögren's syndrome; xerostomia
• Target Audience: 一般
• Note (General): type:Thesis; Objectives: Patients with Sjögren's syndrome (SS) suffer from impaired saliva secretion due to an autoimmune destruction of salivary glands. Based upon its abnormal distribution in SS salivary glands, a potential role for the water channel protein aquaporin-5 (AQP5) is proposed in the pathogenesis of SS. Methods: The immunohistochemical distribution of AQP5 was compared in minor salivary gland (MSG) biopsies obtained from primary SS with a variety of lymphoid cells infiltration in MSG, and healthy volunteers. Results: Biopsies from normal subjects revealed AQP5 primarily at the apical membrane of the salivary gland acinus. In contrast, biopsies from SS patients with both moderate and severe lymphoid infiltration revealed AQP5 expression diffusely at the cytoplasm of the acinus. Computer-assisted microscopy was performed to quantitatively evaluate AQP5 distribution in the acini. Biopsies of SS patients exhibited lower labeling indices (LI) at the apical membrane compared with biopsies from control subjects. The LI of the acini obtained from SS patients with both moderate and severe lymphoid infiltration showed no difference. Conclusions: Abnormal distribution of AQP5 in salivary gland acini could be responsible for a loss of saliva secretion, and this abnormal distribution is likely to develop during the stage of moderate lymphoid infiltration in salivary gland.; 博士（医学）・乙1334号・平成26年3月17日; identifier:Journal of Nara Medical Association Vol.64 No.4 p.65-72; identifier:13450069; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2695; identifier:Journal of Nara Medical Association, 64(4): 65-72
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2695/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2695/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2695/3/03%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Periodical Title (NCID): AA11252383; https://ci.nii.ac.jp/ncid/AA11252383
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU