ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score.

• Material Type: 博士論文
• Title: ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score.
• Author/Editor: Takaya, Hiroaki; Uemura, Masahito; Fujimura, Yoshihiro; Matsumoto, Masanori; Matsuyama, Tomomi; Kato, Seiji; Morioka, Chie; Ishizashi, Hiromichi; Hori, Yuji; Fujimoto, Masao; Tsujimoto, Tatsuhiro; Kawaratani, Hideto; Toyohara, Masahisa; Kurumatani, Norio; Fukui, Hiroshi
• Author Heading: Takaya, Hiroaki; Uemura, Masahito; Fujimura, Yoshihiro; Matsumoto, Masanori; Matsuyama, Tomomi; Kato, Seiji; Morioka, Chie; Ishizashi, Hiromichi; Hori, Yuji; Fujimoto, Masao; Tsujimoto, Tatsuhiro; Kawaratani, Hideto; Toyohara, Masahisa; Kurumatani, Norio; Fukui, Hiroshi
• Publication, Distribution, etc.: Wiley / The Japan Society of Hepatology
• Publication Date: 2012-05
• Publication Date (W3CDTF): 2012-05
• Alternative Title: 血漿ADAMTSは肝硬変患者の予後をChild-PughスコアやMELDスコアと同様に生存率を予測できる可能性がある
• Periodical title: Hepatology research
• No. or year of volume/issue: 42 5
• Volume: 42
• Issue: 5
• Pages: 459-472
• ISSN (Periodical Title): ISSN : 1386-6346
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-03-17
• Dissertation Number: 甲第613号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: ADAMTS13 activity; Child-Turcotte-Pugh score; liver cirrhosis; Model for End-Stage Liver Disease score; prognosis
• Target Audience: 一般
• Note (General): type:Thesis; Aim: Decreased plasma ADAMTS13 activity (ADAMTS13:AC) results in accumulation of unusually large von Willebrand factor multimers and platelet thrombi formation. Our aim was to evaluate whether ADAMTS13:AC is a prognostic marker in patients with liver cirrhosis. Methods: Plasma ADAMTS13:AC and its related parameters were examined in 108 cirrhotic patients. Results: ADAMTS13:AC decreased as the severity of liver disease increased (means: controls 100%, Child A-cirrhotics 79%, Child B-cirrhotics 63%, and Child C-cirrhotics 31%). ADAMTS13:AC markedly decreased in the cirrhotics with hepatorenal syndrome, refractory ascites and hepatic encephalopathy. The cumulative survival time was the shortest (median: 4.5 months) in the cirrhotics with severe to moderate ADAMTS13:AC deficiency (<3-25%), followed by those with mild ADAMTS13:AC deficiency (25-50%), and was the longest in those with normal activity (>50%). In contrast, based on the Child-Turcotte-Pugh (CTP) score, Child C-cirrhotics had the worst survival, but the survival probabilities did not differ between Child A and B cirrhotics. Based on the Model for End-Stage Liver Disease (MELD) score, the survival was the worst for the cirrhotics in the fourth quartile, but it was not different among cirrhotics in the first three quartiles. Cox proportional-hazards regression analysis showed that ADAMTS13:AC and serum albumin were independent factors affecting the survival. Conclusions: ADAMTS13:AC concomitantly decreases as the functional liver capacity decreases. This activity may be a useful prognostic marker that is equal or superior to the CTP score and the MELD score to predict not only the short-term prognosis but also the long-term survival of the cirrhotic patients.; 博士（医学）・甲613号・平成26年3月17日; identifier:Hepatology research Vol.42 No.5 p.459-472; identifier:13866346; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2698; identifier:Hepatology research, 42(5): 459-472
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2698/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2698/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2698/3/03%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1111/j.1872-034X.2011.00950.x
• Periodical Title (NCID): AA11140867; https://ci.nii.ac.jp/ncid/AA11140867
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU