Individuals' half-lives for 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in blood: correlation with clinical manifestations and laboratory results in subjects with Yusho.

• Material Type: 博士論文
• Title: Individuals' half-lives for 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in blood: correlation with clinical manifestations and laboratory results in subjects with Yusho.
• Author/Editor: Matsumoto, Shinya; Akahane, Manabu; Kanagawa, Yoshiyuki; Kajiwara, Jumboku; Todaka, Takashi; Yasukawa, Fumiko; Uchi, Hiroshi; Furue, Masutaka; Imamura, Tomoaki
• Author Heading: Matsumoto, Shinya; Akahane, Manabu; Kanagawa, Yoshiyuki; Kajiwara, Jumboku; Todaka, Takashi; Yasukawa, Fumiko; Uchi, Hiroshi; Furue, Masutaka; Imamura, Tomoaki
• Publication, Distribution, etc.: Elsevier Science Ltd
• Publication Date: 2013-08
• Publication Date (W3CDTF): 2013-08
• Alternative Title: 血中の2,3,4,7,8-五塩化ダイベンゾフラン(PeCDF)の個人の半減期：油症患者における臨床症状並びに検診結果との関係
• Periodical title: Chemosphere
• No. or year of volume/issue: 92 7
• Volume: 92
• Issue: 7
• Pages: 772-777
• ISSN (Periodical Title): ISSN : 0045-6535
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-03-17
• Dissertation Number: 乙第1325号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Dibenzofuran; Cedar pollen allergy; Yusho; Half-life; Red blood cell; 2,3,4,7,8-Pentachlorodibenzofuran
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND: In 1968, many people developed dioxin poisoning (Yusho) in Japan. Ingestion of 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF) was considered to be the cause of this poisoning. Although some patients had high concentrations of 2,3,4,7,8-PeCDF in their blood, individuals' half-lives of 2,3,4,7,8-PeCDF were long. OBJECTIVES: To evaluate the relationship between clinical and laboratory parameters and the individual half-life of 2,3,4,7,8-PeCDF in blood. METHODS: Clinical and laboratory data were collected during annual check-ups from 2001 to 2008. We enrolled 71 patients, who were measured more than 3 times, and who had 2,3,4,7,8-PeCDF concentrations in blood >50pgg(-1) lipid. The half-life of 2,3,4,7,8-PeCDF for each patient was estimated using linear regression. Moreover, relationships between clinical and laboratory parameters and individual half-life were investigated by linear regression. RESULTS: A shortened individual half-life for 2,3,4,7,8-PeCDF was significantly correlated with an increased red blood cell count, increased viscous secretions from the meibomian glands, existing black comedones, and severe cedar pollen allergy. CONCLUSIONS: Symptoms that accelerate excretion of lipids from the body, such as viscous secretions from the meibomian glands, may lead to a shorter half-life of 2,3,4,7,8-PeCDF. Red blood cells are related to the half-life of 2,3,4,7,8-PeCDF. However, further studies are required to investigate the excretory mechanism of 2,3,4,7,8-PeCDF.; 博士（医学）・乙1325号・平成26年3月17日; identifier:Chemosphere Vol.92 No.7 p.772-777; identifier:00456535; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2710; identifier:Chemosphere, 92(7): 772-777
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.chemosphere.2013.04.005
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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