Possible peripheral mechanism for taste disorder in rats administered S-1.

• Material Type: 博士論文
• Title: Possible peripheral mechanism for taste disorder in rats administered S-1.
• Author/Editor: Aoki, Kumiko; Obata, Koji; Kurihara, Miyako; Kuniyasu, Hiroki; Kirita, Tadaaki; Takaki, Miyako
• Author Heading: Aoki, Kumiko; Obata, Koji; Kurihara, Miyako; Kuniyasu, Hiroki; Kirita, Tadaaki; Takaki, Miyako
• Publication, Distribution, etc.: Springer-Verlag Tokyo
• Publication Date: 2013-06-04
• Publication Date (W3CDTF): 2013
• Alternative Title: S-1投与ラットにおける味覚障害の想定される末梢メカニズム
• Periodical title: International journal of clinical oncology
• No. or year of volume/issue: Epub ahead of print 2013 Jun 4
• Volume: Epub ahead of print
• Issue: 2013 Jun 4
• ISSN (Periodical Title): ISSN : 1341-9625
• Degree grantor/type: 奈良県立医科大学
• Dissertation Number: 乙第1329号
• Degree Type: 博士（医学）
• Subject Heading: Taste disorder; Anticancer drug administration; Neuropathy; S-1
• Target Audience: 一般
• Note (General): 出版タイプ： VoR; type:Thesis; BACKGROUND: Taste disorders are frequently observed in cancer patients undergoing chemotherapy and are serious adverse events which impair the quality of life (QoL) of the cancer patient. Nevertheless, taste disorder mechanisms in cancer patients undergoing chemotherapy have not yet been fully elucidated. The aim of this study was to reveal taste disorder-related peripheral mechanisms using the two-bottle preference test (TBPT) and histological examination of tongues by hematoxylin-eosin staining and immunohistochemistry with protein-gene product 9.5. METHODS: In the TBPT, one bottle was filled with the 0.01 mM quinine hydrochloride (quinine), as a bitter compound, and the other was filled with water. Doses of 50 and 100 mg kg-1 day-1 S-1 (tegafur/gimeracil/oteracil potassium) are lethal to Wistar rats. Therefore, doses ranging from 2-20 mg kg-1 day-1 were administered to the rats for 3 weeks. The S-1 dose of 2 mg kg-1 day-1 corresponds to the clinical dose administered to cancer patients. The part of the tongue containing the circumvallate papillae was excised the following TBPT. RESULTS: The rate of increase in terms of the average preference rate for the quinine vs. all intake (quinine plus water) was significant from the initial S-1 period to the final one, compared with that in control rats, suggesting the possibility of a worsening sensation for the bitter taste. In S-1 rats, the area of taste nerve fibers were significantly decreased and the rate of degeneration of intra-tongue ganglionic nerve cells was significantly increased. These changes were significantly correlated with the rate of increase in average preference rate of the quinine. CONCLUSION: Neuropathy of the gustatory nerve at the periphery may be involved in taste disorders induced by an anticancer drug.; 博士（医学）・乙1329号・平成26年3月17日; © Japan Society of Clinical Oncology 2013; This is a post-peer-review, pre-copyedit version of an article published in International journal of clinical oncology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10147-013-0572-3.; identifier:International journal of clinical oncology Vol.19 No.3 p.549-556 (2014); identifier:13419625; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2714; identifier:International journal of clinical oncology, Epub ahead of print(2013 Jun 4)
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2714/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2714/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2714/3/03%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s10147-013-0572-3; https://doi.org/10.1007/s10147-013-0572-3
• Periodical Title (NCID): AA11086579; https://ci.nii.ac.jp/ncid/AA11086579
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU