Persistent overexpression of SERCA2a affects bladder functions under physiological conditions, but not in bladder outlet obstruction-induced sub-acute pathological conditions.

• Material Type: 博士論文
• Title: Persistent overexpression of SERCA2a affects bladder functions under physiological conditions, but not in bladder outlet obstruction-induced sub-acute pathological conditions.
• Author/Editor: Yamada, Atsushi; Torimoto, Kazumasa; Obata, Koji; Hirayama, Akihide; Fujimoto, Kiyohide; Takaki, Miyako
• Author Heading: Yamada, Atsushi; Torimoto, Kazumasa; Obata, Koji; Hirayama, Akihide; Fujimoto, Kiyohide; Takaki, Miyako
• Publication, Distribution, etc.: Physiological Society of Japan / Springer Japan
• Publication Date: 2014-01
• Publication Date (W3CDTF): 2014-01
• Alternative Title: SERCA2aの持続的過剰発現は、生理的条件下では膀胱機能に影響を及ぼすが、膀胱出口部閉塞亜急性期の病的条件下では膀胱機能に影響しない
• Periodical title: The journal of physiological science
• No. or year of volume/issue: 64 1
• Volume: 64
• Issue: 1
• Pages: 21-30
• ISSN (Periodical Title): ISSN : 1880-6546
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-05-28
• Dissertation Number: 甲第623号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Rat bladder; SERCA2 overexpression; Cystometry; Outlet obstruction; Hypertrophy
• Target Audience: 一般
• Note (General): type:Thesis; A functional impairment of the bladder and heart in a decompensated state caused by a pressure overload is accompanied by a decrease in the sarcoplasmic reticulum Ca2+-ATPase (SERCA2). The beneficial effects of SERCA2 overexpression in preserving cardiac functions have been previously reported. The aim of the present study was to investigate the effects of overexpressed SERCA2 on bladder functions under physiological and pathological conditions using partial bladder outlet obstruction (BOO) in SERCA2a transgenic Wistar rats (TG). Bladder cystometry and western blot analysis were performed using the wild-type Wistar rats (WT), TG, and BOO models (WTBOO and TGBOO). Persistent overexpression of SERCA2 induces reduced bladder compliance without hypertrophy in TG. BOO induces reduced bladder compliance and hypertrophy in WT and TG in the sub-acute phase, but persistent overexpression of SERCA2a in TG does not aggravate the bladder compliance and hypertrophy. In conclusion, SERCA2a overexpression affects bladder functions under physiological conditions, but not in BOO-induced sub-acute pathological conditions.; 博士（医学）・甲第623号・平成26年5月28日; identifier:The journal of physiological science Vol.64 No.1 p.21-30; identifier:18806546; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2718; identifier:The journal of physiological science, 64(1): 21-30
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s12576-013-0286-3
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

Table of Contents

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2718/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2718/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2718/6/03%e6%9c%ac%e6%96%87.pdf fulltext