REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms.

• Material Type: 博士論文
• Title: REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms.
• Author/Editor: Kimura, Michitaka; Naito, Hiroshi; Tojo, Takashi; Itaya-Hironaka, Asako; Dohi, Yoshiko; Yoshimura, Mamiko; Nakagawara, Kan-Ichi; Takasawa, Shin; Taniguchi, Shigeki
• Author Heading: Kimura, Michitaka; Naito, Hiroshi; Tojo, Takashi; Itaya-Hironaka, Asako; Dohi, Yoshiko; Yoshimura, Mamiko; Nakagawara, Kan-Ichi; Takasawa, Shin; Taniguchi, Shigeki
• Publication, Distribution, etc.: National Hellenic Research Foundation / Spandidos
• Publication Date: 2013-12
• Publication Date (W3CDTF): 2013-12
• Alternative Title: 肺癌におけるREG Iα遺伝子の発現は、腺癌、肩平上皮癌で異なったメカニズムにより、予後不良を示唆する。
• Periodical title: Oncology reports
• No. or year of volume/issue: 30 6
• Volume: 30
• Issue: 6
• Pages: 2625-2631
• ISSN (Periodical Title): ISSN : 1021-335X
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-05-28
• Dissertation Number: 乙第1339号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: REG family genes; REG Iα gene; lung cancer; prognostic factor; gene expression
• Target Audience: 一般
• Note (General): type:Thesis; The aim of the present study was to evaluate the effects of the REG Iα and REG Iβ genes on lung cancer cell lines, and thereafter, the expression of REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP and REG IV) in lung cancer in relation to patient prognosis was evaluated. Lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) cell lines expressing REG Iα or REG Iβ (HLC-1 REG Iα/Iβ and EBC-1 REG Iα/Iβ) were established, and cell number, cell invasive activity, and anchorage-independent cell growth were compared with these variables in the control cells. The expression levels of REG family genes were evaluated by real-time RT-PCR in surgically resected lung cancers, and disease-specific survival (DSS) curves were generated. The HLC-1 REG Iα/Iβ cell line showed significant increases in cell number and anchorage-independent cell growth compared with the control cells. EBC-1 REG Iα/Iβ cells showed significant increases in cell invasive activity and anchorage-independent cell growth as compared with the control cells. Except for the REG Iβ gene, expression of other REG family genes was observed in the surgically resected samples; however, DSS was significantly worse only in stage I patients who were positive for REG Iα expression than in patients who were negative for REG Iα expression. The effects of REG Iα on AD and SCC cells were different in the in vitro study, and a correlation between REG Iα expression and patient prognosis was noted in the in vivo study. Therefore, overexpression of REG Iα is a risk factor for poor prognosis caused by discrete mechanisms in AD and SCC patients.; 博士（医学）・乙第1339号・平成26年5月28日; 本文のリンク：http://dx.doi.org/10.3892/or.2013.2739; Copyright © Spandidos Publications 2014; identifier:Oncology reports Vol.30 No.6 p.2625-2631; identifier:1021335X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2723; identifier:Oncology reports, 30(6): 2625-2631
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3892/or.2013.2739
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2723/5/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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