Distribution of bone mineral content is associated with body weight and exercise capacity in patients with chronic obstructive pulmonary disease.

• Material Type: 博士論文
• Title: Distribution of bone mineral content is associated with body weight and exercise capacity in patients with chronic obstructive pulmonary disease.
• Author/Editor: Yamamoto, Yoshifumi; Yoshikawa, Masanori; Tomoda, Koichi; Fujita, Yukio; Yamauchi, Motoo; Fukuoka, Atsuhiko; Tamaki, Shinji; Koyama, Noriko; Kimura, Hiroshi
• Author Heading: Yamamoto, Yoshifumi; Yoshikawa, Masanori; Tomoda, Koichi; Fujita, Yukio; Yamauchi, Motoo; Fukuoka, Atsuhiko; Tamaki, Shinji; Koyama, Noriko; Kimura, Hiroshi
• Publication, Distribution, etc.: Karger AG
• Publication Date: 2014-02
• Publication Date (W3CDTF): 2014-02
• Alternative Title: 慢性閉塞性肺疾患患者における骨塩量の分布と体重および運動能との関連
• Periodical title: Respiration
• No. or year of volume/issue: 87 2
• Volume: 87
• Issue: 2
• Pages: 158-164
• ISSN (Periodical Title): ISSN : 0025-7931
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-07-22
• Dissertation Number: 乙第1341号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: bone mineral content; COPD; body mass index; exercise capacity
• Target Audience: 一般
• Note (General): type:Thesis; Background: Although low bone mineral density is highly prevalent in patients with chronic obstructive pulmonary disease (COPD), the distribution of the reduced bone mass has not been fully elucidated. Objectives: To determine regional bone mass loss in patients with COPD and investigate whether the change in distribution may be associated with body weight loss and functional capacity. Methods: Body mass index (BMI) was assessed, and height squared indices were derived for the bone mineral content index (BMCI) of the arms, legs and trunk by dual-energy X-ray absorptiometry in 45 male patients with COPD and 12 age- and sex-matched control subjects. Pulmonary function tests were performed, and maximal oxygen uptake (V·O2max) was measured. Results: The BMCI was lower in the total bone, legs and trunk of patients with COPD than in control subjects, although the BMCI in the arms was similar between the groups. BMI correlated significantly with the BMCI in all 3 segments. Bone mineral content (BMC) in the trunk, expressed as a percentage of total BMC (BMC trunk/total BMC), correlated significantly with BMI. The BMCI in the trunk was closely related with V·O2max but not with airflow limitation. Conclusions: There was a regional difference in BMC reduction, but a predominant reduction of bone mass in the trunk was not associated with the severity of airflow limitation but rather with body weight loss and exercise intolerance. These data suggest that body weight loss and exercise intolerance are important risk factors for vertebral fracture in patients with COPD.; 博士（医学）・乙第1341号・平成26年7月22日; The definitive version is available at " http://dx.doi.org/10.1159/000355095 "; identifier:Respiration Vol.87 No.2 p.158-164; identifier:00257931; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2744; identifier:Respiration, 87(2): 158-164
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1159/000355095
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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