Quantitative lung perfused blood volume imaging on dual-energy CT: capability for quantitative assessment of disease severity in patients with acute pulmonary thromboembolism.

• Material Type: 博士論文
• Title: Quantitative lung perfused blood volume imaging on dual-energy CT: capability for quantitative assessment of disease severity in patients with acute pulmonary thromboembolism.
• Author/Editor: Miura, Sachiko; Ohno, Yoshiharu; Kimura, Hiroshi; Kichikawa, Kimihiko
• Author Heading: Miura, Sachiko; Ohno, Yoshiharu; Kimura, Hiroshi; Kichikawa, Kimihiko
• Publication, Distribution, etc.: Sage / Foundation Acta Radiologica
• Publication Date: 2014-02-24
• Publication Date (W3CDTF): 2014-02-24
• Alternative Title: Dual-Energy CTを用いた肺血液量画像の定量的評価：急性肺血栓塞栓症患者に対する定量的重症度評価
• Periodical title: Acta radiologica
• No. or year of volume/issue: 56 3
• Volume: 56
• Issue: 3
• Pages: 284-293
• ISSN (Periodical Title): ISSN : 0284-1851
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-12-03
• Dissertation Number: 乙第1350号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: CT; Lung; dual-energy CT; perfusion; pulmonary thromboembolism
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND:Regional iodine distribution assessment on dual-energy computed tomography (DECT) has been suggested as useful for management of acute pulmonary thromboembolism (APTE) patients. However, no reported studies have made a direct comparison between quantitatively assessed DECT and right-to-left ventricular (RV/LV) ratio on CT for differentiation of right heart dysfunction (RHD) from non-right heart dysfunction (NRHD) in APTE patients. PURPOSE:To determine the capability of DECT for differentiation of RHD from NRHD in APTE patients. MATERIAL AND METHODS:Thirteen APTE patients underwent DECT and echocardiography at onset of APTE. Patients were divided into RHD (n = 7) and NRHD (n = 6) groups based on echocardiography. A normalized lung perfused blood volume map was generated, and two kinds of overall perfusion (OP) index were determined, one placed over each lung field (OP index A) and as the average from six regions of interest (ROIs) placed over each lung field (OP index B). The heterogeneity index was also determined as the standard deviation for the six ROIs. RV/LV ratio evaluations were also performed. To assess differences between the two groups, each index was statistically compared with the Mann-Whitney U test. The receiver-operating curve-based positive test was then performed to determine the feasible threshold value for dividing patients into the two groups. Finally, differentiation capabilities of the indexes were compared using McNemar's test. RESULTS:Significant differences between the two groups were found for both OP indexes and RV/LV ratio (P < 0.05). For each of the feasible threshold values, accuracy of each OP index with and without RV/LV ratio was better than that of the RV/LV ratio. CONCLUSION:Quantitative DECT has good potential for differentiation of APTE patients with and without right heart dysfunction.; 博士（医学）・乙第1350号・平成26年12月3日; © The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.To access the final edited and published work see http://dx.doi.org/10.1177/0284185114524953.; identifier:Acta radiologica Vol.56 No.3 p.284-293 (2015 Mar); identifier:02841851; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2754; identifier:Acta radiologica, 56(3): 284-293
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1177/0284185114524953
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2754/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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