Follow-up study of unilateral renal function after nephrectomy assessed by glomerular filtration rate per functional renal volume.

• Material Type: 博士論文
• Title: Follow-up study of unilateral renal function after nephrectomy assessed by glomerular filtration rate per functional renal volume.
• Author/Editor: Hosokawa, Yukinari; Tanaka, Nobumichi; Mibu, Hisakazu; Anai, Satoshi; Torimoto, Kazumasa; Yoneda, Tatsuo; Hirayama, Akihide; Yoshida, Katsunori; Hayashi, Yoshiki; Hirao, Yoshihiko; Fujimoto, Kiyohide
• Author Heading: Hosokawa, Yukinari; Tanaka, Nobumichi; Mibu, Hisakazu; Anai, Satoshi; Torimoto, Kazumasa; Yoneda, Tatsuo; Hirayama, Akihide; Yoshida, Katsunori; Hayashi, Yoshiki; Hirao, Yoshihiko; Fujimoto, Kiyohide
• Publication, Distribution, etc.: BioMed Central
• Publication Date: 2014-03-19
• Publication Date (W3CDTF): 2014-03-19
• Alternative Title: 機能的腎体積あたりの腎機能の影響を考慮した腎摘除後の残存腎機能の検討
• Periodical title: World journal of surgical oncology
• No. or year of volume/issue: 12
• Volume: 12
• Pages: Article No.59-
• ISSN (Periodical Title): ISSN : 1477-7819
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-03-16
• Dissertation Number: 乙第1355号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Functional renal parenchymal volume; eGFR; Proteinuria; Renal surgery
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND: To evaluate the clinical usefulness of estimated glomerular filtration rate (eGFR) divided by functional renal volume (FRV) measured by three-dimensional image reconstruction (eGFR/FRV) for the prediction of functional outcomes after nephrectomy. METHODS: Eighty-three patients who underwent nephrectomy were enrolled. The FRV of each patient was measured before surgery. Preoperative medical information on proteinuria, blood pressure, blood glucose level, body mass index (BMI), hemoglobin level and serum cholesterol level were also obtained. We evaluated the relationships between eGFR/FRV and each of these parameters before surgery. We also assessed the potential relationship between eGFR/FRV and the 3-year postoperative eGFR. Stepwise multiple regression analyses were conducted to elucidate independent factors. RESULTS: The median FRV and eGFR were 310.15 cm3 and 79.0 ml/min/1.73 m² before surgery, respectively. The correlation between FRV and eGFR was statistically significant (r = 0.465, P < 0.001). The median eGFR/FRV was 0.24 ml/min/1.73 m²/cm³. Stepwise multiple regression analysis showed that the independent parameters (multiple correlation coefficient, r = 0.389, P = 0.031) associated with eGFR/FRV were proteinuria, BMI, age and hypertension. Proteinuria was statistically associated with eGFR/FRV, and the independent parameters (multiple correlation coefficient, r = 0.694, P < 0.001) associated with the 3-year postoperative eGFR were age, BMI and eGFR/FRV. The eGFR/FRV was statistically associated with the 3-year postoperative eGFR (r = 0.559, P < 0.001). CONCLUSION: The present results demonstrated that patients with proteinuria are expected to have a lower eGFR/FRV than those without proteinuria. The present study also supports the notion that eGFR/FRV is the primary determinant of the long-term functional outcome after nephrectomy. It should be taken into consideration that patients with a low eGFR/FRV may develop chronic kidney disease after nephrectomy.; 博士（医学）・乙第1354号・平成27年3月16日; © 2014 Hosokawa et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.; identifier:World journal of surgical oncology Vol.12 Article No.59 (2014); identifier:14777819; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2974; identifier:World journal of surgical oncology, 12: Article No.59
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1186/1477-7819-12-59
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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