Clinical impact of herpesvirus entry mediator expression in human hepatocellular carcinoma.

• Material Type: 博士論文
• Title: Clinical impact of herpesvirus entry mediator expression in human hepatocellular carcinoma.
• Author/Editor: Hokuto, Daisuke; Sho, Masayuki; Yamato, Ichiro; Yasuda, Satoshi; Obara, Shinsaku; Nomi, Takeo; Nakajima, Yoshiyuki
• Author Heading: Hokuto, Daisuke; Sho, Masayuki; Yamato, Ichiro; Yasuda, Satoshi; Obara, Shinsaku; Nomi, Takeo; Nakajima, Yoshiyuki
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2015-01
• Publication Date (W3CDTF): 2015-01
• Alternative Title: ヒト肝細胞癌においてherpesvirus entry mediatorの発現がもたらす影響
• Periodical title: European journal of cancer
• No. or year of volume/issue: 51 2
• Volume: 51
• Issue: 2
• Pages: 157-165
• ISSN (Periodical Title): ISSN : 0959-8049
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-05-28
• Dissertation Number: 乙第1359号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: HVEM; HCC; TIL; Prognosis; Tumour immunity; TNFRSF14
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND: Herpes virus entry mediator (HVEM), also known as tumour necrosis factor receptor (TNFR) superfamily 14, regulates a variety of physiological and pathological responses in both innate and acquired immunity. Although HVEM is also suggested to be a critical regulator in tumours, actual roles in human cancer are largely unknown. This study aimed to clarify clinical importance of HVEM in human hepatocellular carcinoma (HCC). PATIENTS AND METHODS: We studied HVEM expression in 150 HCC patients to explore its clinical relevance, and we examined tumour infiltrating T cells and local immune status of them. RESULTS: HVEM was expressed in HCC cells, while no or only limited expression was observed in normal tissues in the liver. Tumour HVEM expression was significantly correlated with age, serum protein induced by vitamin K absence or antagonist-II (PIVKA-II) level, vascular invasion and tumour node metastasis (TNM) stage. Furthermore, tumour HVEM expression significantly correlated with postoperative recurrence and survival. Importantly, multivariate analysis indicated that the HVEM status had an independent prognostic value. Furthermore, HVEM status was inversely correlated with tumour-infiltrating CD4(+), CD8(+) and CD45RO(+) lymphocytes. In addition, it was also associated with reduced expression of perforin, granzyme B and interferon-γ (IFN-γ). Taken together, tumour-expressing HVEM plays a functionally important role in HCC. CONCLUSION: Tumour-expressing HVEM plays a critical role in human HCC, possibly through regulating immune evasion. Therefore, targeting HVEM may be a novel promising therapeutic strategy for HCC.; 博士（医学）・乙第1359号・平成27年5月28日; Copyright © 2014 Elsevier Ltd.; identifier:European journal of cancer Vol.51 No.2 p.157-165(2015.01); identifier:09598049; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3072; identifier:European journal of cancer, 51(2): 157-165
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.ejca.2014.11.004
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3072/1/01_%e4%b9%991359%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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