The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit.

• Material Type: 博士論文
• Title: The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit.
• Author/Editor: Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, Shin; Takahashi, Yukihiro
• Author Heading: Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, Shin; Takahashi, Yukihiro
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2015-08
• Publication Date (W3CDTF): 2015-08
• Alternative Title: CD38 genotype (rs1800561 (4693C > T): R140W)は新生児集中治療室への入院のリスク増加に関連する
• Periodical title: Early human development
• No. or year of volume/issue: 91 8
• Volume: 91
• Issue: 8
• Pages: 467-470
• ISSN (Periodical Title): ISSN : 0378-3782
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-11-27
• Dissertation Number: 甲第639号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: CD38; Preterm birth; OXTR; SNP
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUNDS:Preterm birth (PTB)/admission to the neonatal intensive care unit (NICU) is a complex disorder associated with significant neonatal mortality and morbidity and long-term adverse health consequences. Multiple lines of evidence suggest that genetic factors play an important role in its etiology. AIM:Given the role of CD38 in term delivery through oxytocin (OXT) release, we hypothesized that OXT signaling may play a role in the etiology of PTB/admission to the NICU. This study was designed to identify genetic variation in the CD38-oxytocin pathway associated with PTB/admission to the NICU. METHODS:To identify common genetic variants predisposing individuals to PTB/admission to the NICU, we genotyped two single nucleotide polymorphisms (SNPs) in the CD38-oxytocin pathway in 63 case mothers, 55 control mothers, and 188 female volunteers in Nara Medical University Hospital, Japan. RESULTS:Maternal genetic effect analysis of the SNP genotype data revealed a significant association between an SNP in CD38 (rs1800561 (4693C>T): R140W), which was reported to be correlated with diabetes and autism, and the risk of NICU admission. On the other hand, an SNP in the oxytocin receptor (OXTR) (rs2254298) showed no correlation with the risk of NICU admission. CONCLUSION:Our study points to an association between maternal common polymorphisms in the CD38 (rs1800561) gene in Japanese women and susceptibility to PTB/admission to the NICU. Future studies with larger sample sizes are needed to confirm the findings of this study.; 博士（医学）・甲第639号・平成27年11月27日; Copyright © 2015 Elsevier B.V. All rights reserved.; identifier:Early human development Vol.91, No.8 p.467-470(2015 Aug); identifier:03783782; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3100; identifier:Early human development, 91(8): 467-470
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.earlhumdev.2015.05.002
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3100/1/01_%e7%94%b2639%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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